Results 11 to 20 of about 132,202 (243)
It was shown by Meltzer and Auer in 1905 that the primary effect of magnesium upon the nerve cells is that of paralysis without any preceding excitation. The effect seemed to be exclusively of an inhibitory character. They injected subcutaneously into rabbits varying amounts of a 25 per cent solution of magnesium sulphate.
openaire +3 more sources
Deletion of the gabra2 gene results in hypersensitivity to the acute effects of ethanol but does not alter ethanol self administration [PDF]
Human genetic studies have suggested that polymorphisms of the GABRA2 gene encoding the GABA(A) α2-subunit are associated with ethanol dependence. Variations in this gene also convey sensitivity to the subjective effects of ethanol, indicating a role in ...
A Agrawal+46 more
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Quiet Time for Mechanically Ventilated Patients in The Medical Intensive Care Unit [PDF]
Objective: Sleep disruption occurs frequently in critically ill patients. The primary aim of this study was to examine the effect of quiet time (QT) on patient sedation frequency, sedation and delirium scores; and to determine if consecutive QTs ...
Bartick+37 more
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The SEDs of interacting galaxies [PDF]
AbstractThe evolution of galaxies is greatly influenced by their interactions. As part of a program to study interacting galaxies, we have measured and modeled the spectral energy distributions (SEDs) from the ultraviolet (UV) to the far-infrared (FIR).
Elisabete da Cunha+10 more
openaire +4 more sources
The implausibility of ‘usual care’ in an open system: sedation and weaning practices in Paediatric Intensive Care Units (PICUs) in the United Kingdom (UK) [PDF]
Background: The power of the randomised controlled trial depends upon its capacity to operate in a closed system whereby the intervention is the only causal force acting upon the experimental group and absent in the control group, permitting a valid ...
B Ambuel+34 more
core +1 more source
Do antidepressants cure or create abnormal brain states? [PDF]
Moncrieff and Cohen argue that psychotropic drugs create abnormal states that may co-incidentally relieve symptoms of mental ...
Beasley+55 more
core +3 more sources
Differential Actions of Ethanol and Trichloroethanol at Sites in the M3 and M4 Domains of the NMDA Receptor GluN2A (NR2A) Subunit [PDF]
Background and purpose: Alcohol produces its behavioural effects in part due to inhibition of N-methyl-d-aspartate (NMDA) receptors in the CNS. Previous studies have identified amino acid residues in membrane-associated domains 3 (M3) and 4 (M4) of the ...
Hu, Xiang-Qun+5 more
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Butorphanol for Post-Operative Analgesia - A Comparative Clinical Study with Ketorolac [PDF]
Introduction: Butorphanol, an opioid derivative has been shown to have, in addition to its analgesic properties, several other advantageous effects like antistressor, sedative and anti-shivering action.
Adappa, Karunakara+7 more
core +1 more source