Results 51 to 60 of about 195,235 (340)

Speciation Through the Lens of Population Dynamics: A Theoretical Primer on How Small and Large Populations Diverge

Population Ecology, EarlyView.
Population size and dynamics fundamentally shape speciation by influencing genetic drift, founder events, and adaptive potential. Small populations may speciate rapidly due to stronger drift, whereas large populations harbor more genetic diversity, which can alter divergence trajectories. We highlight theoretical models that incorporate population size
Ryo Yamaguchi, Hidaka Kubo, Tokuya Ogawa, Hayate Omura   +3 more
wiley   +1 more source

Butorphanol for Post-Operative Analgesia - A Comparative Clinical Study with Ketorolac [PDF]

, 2010
Introduction: Butorphanol, an opioid derivative has been shown to have, in addition to its analgesic properties, several other advantageous effects like antistressor, sedative and anti-shivering action.
Adappa, Karunakara, Kadam, Dinesh, Kadri, Rajani, Koteshwar, Reshma, Mohan, Prashanth, Shenoy, Sunil P, Tantry, Thrivikrama Padur, Vastrad, Nandish S   +7 more
core   +1 more source

Is there a potential of misuse for Magnolia officinalis compounds/metabolites? [PDF]

, 2017
© 2017 John Wiley & Sons, Ltd.Objective: Magnolia bark contains magnolol, metabolized to tetrahydromagnolol and honokiol, with both GABA-ergic/cannabimimetic activities, hence of possible attraction to vulnerable individuals/recreational misusers ...
Alexeev, Böhmdorfer, Chiou, Coppola, Fattore, Fuchs, Fuchs, Garrison, Hattori, Kalman, Kao, Kotani, Kuribara, Lee, Lee, Lin, Liu, Mantani, Nakazawa, Oikawa, Papanti, Rempel, Schifano, Schifano, Schifano, Siemann, Sohn, Squires, Tsai, Tsai, Wang, Watanabe, Xu   +32 more
core   +3 more sources

Use of Sedative-Hypnotics and Mortality: A Population-Based Retrospective Cohort Study.

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2018
STUDY OBJECTIVES Researchers have previously reported a possible association between sedative-hypnotics and increased mortality. However, the relationship remains controversial.
J. Choi, Joonki Lee, S. Jung, A. Shin, Y. Lee   +4 more
semanticscholar   +1 more source

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Factors associated with euphoria in a large subset of cases using propofol sedation during gastrointestinal endoscopy

Frontiers in Psychiatry, 2023
BackgroundThe utilization of Propofol, a widely used intravenous sedative or anesthetic, is characterized by its quick onset, predictable control, and fleeting half-life during both general anesthesia and intensive care unit sedation.
Kaixuan Zhao, Ning Yang, Jingli Yue, Ying Han, Xiaoxiao Wang, Ning Kang, Tianhao Zhang, Xiangyang Guo, Mao Xu   +8 more
doaj   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Effects of Patient-Directed Music Intervention on Anxiety and Sedative Exposure in Critically Ill Patients Receiving Mechanical Ventilatory Support: A Randomized Clinical Trial [PDF]

, 2013
Importance: Alternatives to sedative medications, such as music, may alleviate the anxiety associated with ventilatory support. Objective: To test whether listening to self-initiated patient-directed music (PDM) can reduce anxiety and sedative exposure ...
Chlan, Linda L., Guttormson, Jill L., Heiderscheidt, Annie, Savik, Kay, Skaar, Debra J., Tracy, Mary Fran, Weinert, Craig R.   +6 more
core   +3 more sources

Pharmacological interventions for the management of anesthesia and sedation in patients with Duchenne muscular dystrophy: a systematic review and meta-analysis

Frontiers in Medicine
BackgroundPatients with duchenne muscular dystrophy (DMD) have an increased risk of complications when they undergo sedation or general anesthesia. However, due to improvements in cardiopulmonary therapies during anesthetic care, patients with DMD are ...
Xianghong Lian, Xianghong Lian, Xianghong Lian, Yang Jing, Yang Jing, Yang Jing, Ting Luo, Ting Luo, Ting Luo, Yixin Guo, Yixin Guo, Yixin Guo, Yunzhu Lin, Yunzhu Lin, Yunzhu Lin   +14 more
doaj   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source