Results 71 to 80 of about 145,536 (303)

Prognostic Implications of Sleep Architecture for Patients Admitted to the Intensive Care Unit With Status Epilepticus

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Status epilepticus (SE) is associated with significant mortality. Sleep architecture may reflect normal brain function. Impaired sleep architecture is associated with poorer outcomes in numerous conditions. Here we investigate the association of sleep architecture in continuous EEG (cEEG) with survival in SE.
Ran R. Liu   +5 more
wiley   +1 more source

ACTION OF BIOLOGICALLY ACTIVE COMPOUNDS - DERIVATIVES OF 4-OXOPYRIMIDINE ON THE BEHAVIOR OF MALE RATS IN THE «OPEN FIELD»

open access: yesВестник Северо-Кавказского федерального университета, 2022
The article reveals how when tested in open field was investigated range of activity (sedative, activating and anxiolytic effect) of biologically active compounds - derivatives of 4 - oxo - pyrimidine with acute and chronic administration of a dose 50 mg
Eleonora A. Manveljan   +3 more
doaj  

Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron   +5 more
wiley   +1 more source

A Comparison of Moderate Oral Sedation Drug Regimens for Pediatric Dental Treatment: A Pilot Study [PDF]

open access: yes, 2017
Purpose: Compare moderate oral sedation of pediatric patients using Hydroxyzine and Meperidine with either Diazepam or Midazolam in management of pediatric dental patients. Methods: Randomized, double-blind, crossover pilot study of patients 3 to 7 years
Parikh, Ojas A
core   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi   +2 more
wiley   +1 more source

Effect of Thai traditional antinausea remedy on hypnotic and sedative activity in animal experimental models: Interaction with drugs acting at GABAA receptor

open access: yesJournal of Advanced Pharmaceutical Technology & Research, 2019
Thai traditional antinausea remedy is drug registered in the National List of Essential Medicines for the treatment of blood circulation disorders, dizziness, fatigue, and insomnia.
Watchara Damjuti   +2 more
doaj   +1 more source

Sedation for Gastrointestinal Endoscopic Procedures in the Elderly: Getting Safer but Still Not Nearly Safe Enough [PDF]

open access: yes, 2006
Previously published UK reports showed that excessively large doses of benzodiazepines and opiates were being commonly used to sedate elderly patients for gastrointestinal (GI) endoscopy. This unsafe practice has lead to avoidable morbidity and mortality.
Bell, G. D.   +8 more
core  

Effects of Chlordiazepoxide on Predator Odor-Induced Reductions of Playfulness in Juvenile Rats

open access: yes, 2010
The extent to which a non-sedative dose of chlordiazepoxide (CDP) is able to modify the behavioral responses toward a predator odor was assessed in juvenile rats.
DeBrouse, Lauren M.   +2 more
core   +1 more source

Offset of pharmacodynamic effects and safety of remifentanil in intensive care unit patients with various degrees of renal impairment [PDF]

open access: yes, 2003
Introduction: This open label, multicentre study was conducted to assess the times to offset of the pharmacodynamic effects and the safety of remifentanil in patients with varying degrees of renal impairment requiring intensive care. Methods: A total of
Breen, Des   +7 more
core   +1 more source

ALS With and Without Upper Motor Neuron Signs: A Comparative Study Supporting the Gold Coast Criteria

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The Gold Coast criteria permit diagnosis of amyotrophic lateral sclerosis (ALS) even without upper motor neuron (UMN) signs. However, whether ALS patients with UMN signs (ALSwUMN) and those without (ALSwoUMN) share similar characteristics and prognoses remains unclear.
Hee‐Jae Jung   +7 more
wiley   +1 more source

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