Results 111 to 120 of about 584,671 (296)
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
Journal of Hydrology: Regional StudiesStudy region: This study focuses on the middle Yangtze River's ecologically vital but hydrologically vulnerable wetlands: the Poyang Lake Plain and Dongting Lake Plain, China.
Pinjian Li +7 more
doaj +1 more source
Sedimentation of microplastics interacting with sediment
The widespread presence of microplastics (MPs) in freshwater environments underscores the need to better understand their temporal and spatial dynamics. Investigating the settling velocity (W) of MPs in the water column is crucial for comprehending their transport mechanisms within river systems.
Mancini, Mirco +4 more
openaire +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Effects of growth and starvation conditions on bacterial adhesion to plastic surfaces
National Science OpenThe effects of nutrient conditions on the formation of plastisphere were unclear. This study investigated the impacts of growth and starvation conditions on the adhesion of both Gram-negative and Gram-positive bacteria to six plastics in both salt ...
He Lei +3 more
doaj +1 more source
Eos, Transactions American Geophysical Union, 1971 Research activities in erosion and sedimentation processes have expanded broadly during the past several years and have kept pace with generally accelerated developments in all phases of hydrology and water resources investigations.
openaire +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
HydrologyThis study analyzes the hydro-morphological dynamics of the lower 40 km of the Magdalena River (Colombia), with particular emphasis on the reach between Malambo and the river mouth at Bocas de Ceniza.
Allen Bateman Pinzón, Raúl Sosa Pérez
doaj +1 more source