Results 101 to 110 of about 584,671 (296)
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Assessing the importance of river bank erosion for fine sediment delivery to Bassenthwaite Lake [PDF]
, 2007 Available evidence from lake sediment core records and short-term sediment flux sampling programs has suggested increased fine sediment deposition and suspended sediment transfers to Bassenthwaite Lake, Cumbria, U.K over recent decades. This increase in
Hopkins, Jonathan
core
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Role of sediment in the design and management of irrigation canals : Sunsari Morang Irrigation Scheme, Nepal [PDF]
, 2010 Sediment transport in irrigation canals The sediment transport aspect is a major factor in irrigation development as it determines to a large extent the sustainability of an irrigation scheme, particularly in case of unlined canals in alluvial soils ...
Paudel, K.
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Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk
Molecular Oncology, EarlyView.Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley +1 more source
Earth Critical ZoneN2O is a potent greenhouse gas with strong impacts on global warming and ozone layer depletion. The well characterized nitric oxide reductases, cNor and qNor, have known roles in denitrification, while several additional clades—eNor, gNor, nNor, and sNor—
Shengjie Li +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
SPATIAL AND TEMPORAL DYNAMICS OF FINE FLUVIAL SEDIMENT TRANSFER: IMPLICATIONS FOR MONITORING AND MANAGEMENT OF UPLAND RIVER SYSTEMS [PDF]
, 2013 Although the impacts of changing land use on the magnitude and timing of erosion in lowland catchments are well documented, much less is known about the transfer dynamics of fine sediment through the upland hydrological networks.
PERKS, MATTHEW,THOMAS
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Nature CommunicationsFerrate (Fe(VI)) is a prospective green oxidant owing to producing highly reactive Fe(IV)/Fe(V) for micropollutant degradation. However, the performance is significantly compromised by the severe side reaction of Fe(VI) self-decay with H2O, generating ...
Yundan Chen +4 more
doaj +1 more source