Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Dynamics of fluvial fine sediment transfer in the River Esk, North Yorkshire, UK [PDF]
, 2006 A full understanding of the complexities of fluvial suspended sediment dynamics requires a holistic approach. The study presented here addresses fine sediment transfer in the River Esk catchment, which is suffering from the adverse effects of increased ...
Mills, Carolyn
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
SPATIAL AND TEMPORAL DYNAMICS OF FINE FLUVIAL SEDIMENT TRANSFER: IMPLICATIONS FOR MONITORING AND MANAGEMENT OF UPLAND RIVER SYSTEMS [PDF]
, 2013 Although the impacts of changing land use on the magnitude and timing of erosion in lowland catchments are well documented, much less is known about the transfer dynamics of fine sediment through the upland hydrological networks.
PERKS, MATTHEW,THOMAS
core
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
The Dynamics of Coarse Sediment Transfer in an Upland Bedrock River [PDF]
, 2010 Bedrock channels in UK upland environments have received relatively little attention despite their importance within upland river systems and their influence on controlling the conveyance of sediment downstream. This thesis aims to quantify and model the
CRAY, ALISTAIR,IAN
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The use of artificial neural networks to analyze and predict alongshore sediment transport [PDF]
, 2010 An artificial neural network (ANN) was developed to predict the depth-integrated alongshore suspended sediment transport rate using 4 input variables (water depth, wave height and period, and alongshore velocity).
Coco, Giovanni +10 more
core +2 more sources
The application of backpropagation neural network method to estimate the sediment loads
MATEC Web of Conferences, 2017 Nearly all formulations of conventional sediment load estimation method were developed based on a review of laboratory data or data field. This approach is generally limited by local so it is only suitable for a particular river typology.
Ari Gunawan Taufik +3 more
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Assessing the importance of river bank erosion for fine sediment delivery to Bassenthwaite Lake [PDF]
, 2007 Available evidence from lake sediment core records and short-term sediment flux sampling programs has suggested increased fine sediment deposition and suspended sediment transfers to Bassenthwaite Lake, Cumbria, U.K over recent decades. This increase in
Hopkins, Jonathan
core