Results 91 to 100 of about 18,063 (294)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Statistical modelling of suspended sediment transport in the Cherf drainage basin, Algeria

Revue Marocaine des Sciences Agronomiques et Vétérinaires, 2012
This work deals with the main topic of the assessment of the Cherf drainage basin sediment yield based on available water discharge and suspended sediment concentration observations, and on the application of general and multivariate models.
K. KHANCHOUL, Z-E BOUKHRISSA, H. MAJOUR
doaj  

Water Quality Sampling, Analysis and Annual Load Determinations for Nutrients and Sediment at the Arkansas Highway 45 Bridge on the White River Just Above Beaver Lake [PDF]

, 2006
Automatic water sampler and a U. S. Geological Survey gauging station were established in 1995 on the main stem of the Illinois River at the Arkansas Highway 59 Bridge.
Brahana, J.V., Cash, Wade, Nelson, Marc, Purtle, Jennifer, Trost, Keith   +4 more
core   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Predicting Suspended Sediment Transport in Urbanised Streams: A Case Study of Dry Creek, South Australia

Hydrology
Sediment transport in urban streams is a critical environmental issue, with significant implications for water quality, ecosystem health, and infrastructure management.
Tesfa Gebrie Andualem, Guna A. Hewa, Baden R. Myers, John Boland, Stefan Peters   +4 more
doaj   +1 more source

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

A new approach for estimation suspended sediment yield [PDF]

Hydrology and Earth System Sciences, 1999
A semi-distributed conceptual model, HBV-SED, for estimation of total suspended sediment concentration and yield at the outlet of a catchment was developed and tested through a case study.
R. Lidén, R. Lidén
doaj  

Fluvial Stage-discharge Rating of Wadi Hanifa Main Channel

Journal of King Saud University: Engineering Sciences, 2000
Recent cross-sectional survey of Wadi Hanifa reach, within Arriyadh city, has been analyzed. The analysis includes the estimation of carrying capacity, possible maximum scour depth and sediment transport capacity of the selected reaches.
Abdulaziz A. Alhamid, Md. Abdul Matin
doaj   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

Clinical Validation of Plasma p‐217tau in Neurological Diseases

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma p‐217tau is a minimally invasive but specific biomarker for diagnosing Alzheimer's disease (AD). However, its disease specificity remains to be clinically evaluated. We validated the reliability of the p‐217tau biomarker in 12 other neurological diseases.
Takeshi Kawarabayashi, Takumi Nakamura, Ryoma Takahashi, Tetsuya Ueda, Seiji Kinoshita, Chikage Uchida, Takashi Sugawara, Kentaro Hashimoto, Kunihiko Ishizawa, Masakuni Amari, Hiroo Kasahara, Yoshio Ikeda, Masamitsu Takatama, Mikio Shoji   +13 more
wiley   +1 more source