Results 41 to 50 of about 5,976,198 (283)

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Distribution of Trace Elements, Sr-C Isotopes, and Sedimentary Characteristics as Paleoenvironmental Indicator of the Late Permian Linxi Formation in the Linxi Area, Eastern Inner Mongolia

Journal of Chemistry, 2020
The Late Permian on the periphery of the Songliao Basin, eastern Inner Mongolia, is an important hydrocarbon source rock system. Its sedimentary environment plays an important role in the evaluation of hydrocarbon prospects in the area.
Linlin Wang, Yongsheng Zhang, Enyuan Xing, Yuan Peng, Dongdong Yu   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Tight regulation of Earth’s long-term temperature over Phanerozoic time

Nature Communications
Knowing the past temperature of the Earth is crucial for understanding the mechanisms driving climate change and biosphere evolution, but there is significant debate about the range of past temperature variation.
Dongyu Zheng, Alex G. Lipp, Alexander Farnsworth, Shufeng Li, Andrew S. Merdith, Khushboo Gurung, Mingcai Hou, Anqing Chen, Zixi Hou, Daniel J. Lunt, Erik A. Sperling, Paul J. Valdes, Benjamin J. W. Mills   +12 more
doaj   +1 more source

Research on the Sedimentary and Paleoclimate Environment of the Xiaoheba Formation in Southeastern Sichuan Based on the Trace Elements Ratio Method

Yankuang ceshi, 2017
Lower Silurian sandstone of the Xiaoheba formation in Southeastern Sichuan has a good reservoir seal combination, and an oil and gas geological condition, but the hypothesis that the sedimentary environment belongs to continental or marine sedimentary ...
YANG Hai-ou, WANG Chang-cheng, LI Wen-jie, DONG Hua, GONG Xiao-xing   +4 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Hydrodynamics and sedimentary structures of antidunes in gravel and sand mixtures

, 2008
This thesis firstly reviews the current literature available on antidune bedforms and their hydrodynamic environment, alongside recent studies of the turbulence environments associated with bedforms in unidirectional flow.
Breakspear, Richard
core   +1 more source

Terahertz Dating of Sedimentary Rocks

Frontiers in Physics, 2022
The depositional products of sedimentary rocks provide vital references for investigating the paleoenvironment, paleogeography, and tectonic evolution history.
Zhaohui Meng, Zhaohui Meng, Zhaohui Meng, Honglei Zhan, Honglei Zhan, Honglei Zhan, Ru Chen, Ru Chen, Ru Chen, Xinyang Miao, Xinyang Miao, Xinyang Miao, Kun Zhao, Kun Zhao   +13 more
doaj   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source