Results 51 to 60 of about 176,816 (330)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

A four stage evolution of the White Channel gravel: Implications for stratigraphy and palaeoclimates [PDF]

, 2014
Although the White Channel gravel (WCG) of the Klondike district, Yukon, contains gold placers which have been exploited for over a century, few sedimentological studies have been undertaken.
Chapman, Robert, Lowther, Robert, Peakall, Jeff, Pound, Matthew   +3 more
core  

Comment on Reply to Comment of Finger et al. (2013) on: 'Evidence for an Early-Middle Miocene age of the Navidad Formation (central Chile): Paleontological, paleoclimatic and tectonic implications' of Gutiérrez et al. (2013, Andean Geology 40 (1): 66-78) [PDF]

, 2014
Indexación: Web of Science; ScieloIn their answer to our Comment (Finger et al., 2013), Le Roux et al. (2013) misunderstand several of our remarks and present what we view as f lawed arguments, principally their case for a shallow-marine environment for ...
Contardo, Ximena, Encinas, Alfonso, Finger, Kenneth L., Nielsen, Sven N   +3 more
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

New sedimentary unit with subaqueous facies of Curitiba Sedimentary Basin, Southern Brazil [PDF]

Brazilian Journal of Geology
The Curitiba Sedimentary Basin (CSB) is a small and shallow sedimentary basin, which is part of the Continental Rift of Southeastern Brazil. New exposures allowed for the identification of a subaqueous facies association, named Guatupê Unit, within the ...
Rodolfo José Angulo, Maria Cristina de Souza, Giancarlo Scardia, Eduardo Salamuni, Mitsuru Arai, Fabio Parenti, Luís Augusto Koenig Veiga   +6 more
doaj   +1 more source

Distribution of Trace Elements, Sr-C Isotopes, and Sedimentary Characteristics as Paleoenvironmental Indicator of the Late Permian Linxi Formation in the Linxi Area, Eastern Inner Mongolia

Journal of Chemistry, 2020
The Late Permian on the periphery of the Songliao Basin, eastern Inner Mongolia, is an important hydrocarbon source rock system. Its sedimentary environment plays an important role in the evaluation of hydrocarbon prospects in the area.
Linlin Wang, Yongsheng Zhang, Enyuan Xing, Yuan Peng, Dongdong Yu   +4 more
doaj   +1 more source

Stratigraphic units of the Apulian Tavoliere plain (Southern Italy): Chronology, correlation with marine isotope stages and implications regarding vertical movements

, 2010
The geologic study of the Apulian Tavoliere plain (Apulia region, southern Italy) is extremely difficult due to the scarcity of outcrops and fauna that could be used for dating. The survey in progress of the 1:50,000 scale geological sheet no.
Caldara, Massimo, De Santis, Vincenzo, Ortiz Menéndez, José Eugenio, Torres Pérez-Hidalgo, Trinidad José   +3 more
core   +1 more source

A new model for the formation of microbial polygons in a coastal sabkha setting [PDF]

, 2017
The stratigraphic record of microbially induced sedimentary structures spans most of the depositional record. Today, microbes continue to generate, bind and modify sediments in a vast range of depositional environments.
Andrade, Luiza, Court, Wesley, Dutton, Kirsten, Head, Ian M., Lokier, Stephen, Paul, Andreas, Sherry, Angela, van der Land, Cees   +7 more
core   +2 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Research on the Sedimentary and Paleoclimate Environment of the Xiaoheba Formation in Southeastern Sichuan Based on the Trace Elements Ratio Method

Yankuang ceshi, 2017
Lower Silurian sandstone of the Xiaoheba formation in Southeastern Sichuan has a good reservoir seal combination, and an oil and gas geological condition, but the hypothesis that the sedimentary environment belongs to continental or marine sedimentary ...
YANG Hai-ou, WANG Chang-cheng, LI Wen-jie, DONG Hua, GONG Xiao-xing   +4 more
doaj   +1 more source