Results 21 to 30 of about 11,931 (215)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Astronomical cycle framework and carbonate platform evolution of Permian Longtan Formation–Triassic Feixianguan Formation in Sichuan Basin, SW China

Petroleum Exploration and Development
Based on data from cores, well logs, seismic profiles, and carbon isotopic compositions, this study constrains the chronostratigraphic framework using carbon isotopic excursion events and applies cyclostratigraphic methods to establish a high-resolution ...
Shuyuan Shi, Jiabin Wu, Suyun Hu, Jianguo Zhang, Hua Jiang, Fanzhi Kong, Wei Liu, Jianbing Yun, Hao Meng, Saijun Wu   +9 more
doaj   +1 more source

Jurassic sedimentary evolution of southern Junggar Basin: Implication for palaeoclimate changes in northern Xinjiang Uygur Autonomous Region, China

Journal of Palaeogeography, 2014
Junggar Basin, located in northern Xinjiang, presents continuous and multikilometer-thick strata of the Jurassic deposits. The Jurassic was entirely terrestrial fluvial and lacustrine deltaic sedimentation.
Shun-Li Li, Xing-He Yu, Cheng-Peng Tan, Ronald Steel   +3 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Integrated well-seismic analysis of sedimentary facies distribution: A case study from the Mesoproterozoic, Ordos Basin, China

Open Geosciences
To advance the understanding of Mesoproterozoic sedimentary facies and delineate their distribution patterns in the Ordos Basin, this study systematically analyzes the sedimentary characteristics and stratigraphic architecture of the Mesoproterozoic ...
Gao Longhui, Jing Xianghui, Tian Jingchun, Zhang Tao, Liang Qingshao, Ren Junfeng, Wang Feng   +6 more
doaj   +1 more source

Improving the accuracy of geological models and seismic sedimentology using sedimentary forward modeling

Frontiers in Earth Science
Reservoir description based on geostatistics requires cross well constraints (such as high-quality seismic data) to predict the quality of cross well reservoirs that conform to geological laws.
Fan Zuochun, Fan Zuochun, Hu Changhao, Jiang Shu, Yao Rui, Li Man, Zhao Lintian   +6 more
doaj   +1 more source

Sequence sedimentary evolution and reservoir distribution in the third and fourth members of Sinian Dengying Formation, Gaomo area, Sichuan Basin, SW China

Petroleum Exploration and Development, 2022
Based on comprehensive analysis of cores, thin sections, logging and seismic data, the sequence stratigraphy and sedimentary evolution of the third and fourth members of Sinian Dengying Formation (Deng 3 and Deng 4 members for short) in the Gaomo area of
Lei TAN, Hong LIU, Kang CHEN, Hualing NI, Gang ZHOU, Xuan ZHANG, Wei YAN, Yuan ZHONG, Wenzheng LYU, Xiucheng TAN, Kun ZHANG   +10 more
doaj   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Sedimentary evolution pattern influenced by sequence stratigraphy: a case study of the Nanpu Sag, Bohai Bay Basin, China

Geoscience Letters
Identifying and characterizing sedimentary evolution patterns are crucial for assessing the distributions of source and reservoir rocks, which are fundamental to hydrocarbon exploration.
Zhongqiang Sun, Shuangyue Lin, Guangqun Wang, Longlong Liu, Mengqi Wang   +4 more
doaj   +1 more source