Results 41 to 50 of about 11,931 (215)

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Integrated Lithofacies, Well-Log, and Seismic Identification and Sedimentary Evolution of Local Intraplatform Reef–Shoal Bodies in the Changxing Formation, Pengxi–Wusheng Area, Sichuan Basin

Applied Sciences
Studies of Upper Permian Changxing Formation reef–shoal bodies in the Sichuan Basin have mainly focused on platform-margin belts along the Kaijiang–Liangping trough.
Weijie Tong, Zhonggui Hu, Saijun Wu, Wuren Xie, Liang Xu, Chunyan Deng, Quansheng Cai   +6 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Characterization and Numerical Modeling of Shallow Marine Turbidite Depositional Systems: A Case Study from the Second Member of the Yinggehai Formation, X Gas Field, Yinggehai Basin

Journal of Marine Science and Engineering
Objective: The research on turbid current deposition in shallow Marine shelf environments is relatively weak. Method: Based on three-dimensional seismic, drilling and logging data, etc., the spatio-temporal characterization of the shallow sea turbidity ...
Jiaying Wei, Lei Li, Yong Xu, Guoqing Xue, Zhongpo Zhang, Guohua Zhang   +5 more
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Research progress on geogenic-contaminated high ammonium groundwater

Shuiwen dizhi gongcheng dizhi
Groundwater nitrogen contamination is one of the most prevalent water environment problems worldwide. For a long time, the high concentration of ammonium in groundwater has been attributed to inputs from various human activities.
Yao DU, Yaojin XIONG, Yamin DENG, Yanxin WANG   +3 more
doaj   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Sedimentary environmental evolution in the western bohai sea since the middle pleistocene: integrating geochemical and paleontological records

Frontiers in Earth Science
Aiming to address under-utilized geochemical proxies in the Bohai Sea (BS) due to analytical complexity and diagenetic uncertainty, this study present a 300-kyr high-resolution geochemical and microfossils records from core DZQ01, and identified ...
Shuyu Wu, Shuyu Wu, Shuyu Wu, Shuyu Wu, Hongxian Chu, Hongxian Chu, Maoguo An, Yongcai Feng, Yongcai Feng, Jun Liu, Jun Liu   +10 more
doaj   +1 more source