Results 51 to 60 of about 3,210,388 (357)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Uncertainty Quantification of geochemical and mechanical compaction in layered sedimentary basins [PDF]

, 2017
In this work we propose an Uncertainty Quantification methodology for sedimentary basins evolution under mechanical and geochemical compaction processes, which we model as a coupled, time-dependent, non-linear, monodimensional (depth-only) system of PDEs
Colombo, Ivo, Nobile, Fabio, Porta, Giovanni, Scotti, Anna, Tamellini, Lorenzo   +4 more
core   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Relationship between stratigraphic overlap and sedimentary facies evolution of the Junggar Basin, Northwest China

Scientific Reports
The interaction between the topography of the slope zone on the edge of the basin and the distribution of sediments is crucial for accurately predicting sediment distribution, but few studies emphasize the impact of stratigraphic overlap on the spatial ...
Yuanpei Zhang, Qingchun Meng, Fajun Guo, Aihua Yan, Jun Xie, Hongmei Wang, Zaihe Chen, Xuecai Zhang   +7 more
doaj   +1 more source

Improving the accuracy of geological models and seismic sedimentology using sedimentary forward modeling

Frontiers in Earth Science
Reservoir description based on geostatistics requires cross well constraints (such as high-quality seismic data) to predict the quality of cross well reservoirs that conform to geological laws.
Fan Zuochun, Fan Zuochun, Hu Changhao, Jiang Shu, Yao Rui, Li Man, Zhao Lintian   +6 more
doaj   +1 more source

SILLi 1.0: a 1-D numerical tool quantifying the thermal effects of sill intrusions [PDF]

Geoscientific Model Development, 2018
Igneous intrusions in sedimentary basins may have a profound effect on the thermal structure and physical properties of the hosting sedimentary rocks. These include mechanical effects such as deformation and uplift of sedimentary layers, generation of
K. Iyer, K. Iyer, H. Svensen, D. W. Schmid, D. W. Schmid   +4 more
doaj   +1 more source

Investigating the kinematics of mountain building in Taiwan from the spatiotemporal evolution of the foreland basin and western foothills [PDF]

, 2006
The Taiwanese range has resulted from the collision between the Luzon volcanic arc and the Chinese continental margin, which started about 6.5 Myr ago in the north, and has since propagated southward.
Audet, Avouac, Barr, Barr, Beaumont, Bollinger, Bollinger, Bousquet, Byrne, Carena, Chang, Chapple, Chemenda, Chen, Chen, Chen, Cheng, Chi, Chi, Chou, Clark, Covey, Covey, Covey, Dadson, Dadson, Dahlen, Davis, DeCelles, Deschamps, Dominguez, Dominguez, Dominguez, Dorsey, Faure, Goffe, Hetland, Hickman, Ho, Ho, Horng, Hsu, Hsu, Huang, Hung, Jean Philippe Avouac, Jordan, Kim, Konstantinovskaia, Lai, Lallemand, Lave, Lave, Lee, Lee, Li, Lin, Lin, Lin, Lin, Liu, Loevenbruck, Lyon-Caen, Malavieille, Martine Simoes, McIntosh, Mouthereau, Mouthereau, Mouthereau, Mouthereau, Powell, Pulver, Sella, Seno, Shaw, Shih, Shyu, Shyu, Sibuet, Simoes, Suppe, Suppe, Suppe, Suppe, Suppe, Teng, Teng, Tillman, Turcotte, Waschbusch, Whipple, Willett, Yeh, Yu, Yu, Yue   +95 more
core   +5 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Integrated well-seismic analysis of sedimentary facies distribution: A case study from the Mesoproterozoic, Ordos Basin, China

Open Geosciences
To advance the understanding of Mesoproterozoic sedimentary facies and delineate their distribution patterns in the Ordos Basin, this study systematically analyzes the sedimentary characteristics and stratigraphic architecture of the Mesoproterozoic ...
Gao Longhui, Jing Xianghui, Tian Jingchun, Zhang Tao, Liang Qingshao, Ren Junfeng, Wang Feng   +6 more
doaj   +1 more source

Geological significance of late Mid-Permian stratigraphy in northern and eastern Sichuan Basin, SW China

Shiyou shiyan dizhi, 2021
The Mid-Permian Maokou Formation in the Sichuan Basin shows good petroleum prospectivity. However, knowledge of the stratigraphy in the northern and eastern Sichuan Basin during the late Maokou period are still unclear.
Qianying YAO, Yifeng LIU, Qingchun JIANG, Yi HAO, Jingrui LI, Xueju LÜ, Wang SU, Xiaodong FU   +7 more
doaj   +1 more source