Results 51 to 60 of about 11,931 (215)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Depositional Evolution and Controlling Factors of the Lower–Middle Jurassic in the Kuqa Depression, Tarim Basin, Northwest China

Applied Sciences
The Lower–Middle Jurassic of the Kuqa Depression consists of terrestrial clastic deposits containing coal seams and thick lacustrine mudstones, and is of great significance for oil and gas exploration.
Ming Ma, Changsong Lin, Yongfu Liu, Hao Li, Wenfang Yuan, Jingyan Liu, Chaoqun Shi, Manli Zhang, Fan Xu   +8 more
doaj   +1 more source

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Sedimentary Environment and Evolution of the Lower Cretaceous Jiufotang Formation in the Pijiagou and Tanjiagou Sections, Southern Fuxin Basin, NE China

Applied Sciences
The Lower Cretaceous Jiufotang Formation in the Fuxin Basin contains a proven petroleum system. However, its southern part remains underexplored due to limited drilling and fragmentary sedimentary studies.
Yiming Huang, Shichao Li, Fei Xiao, Lei Shi, Yulai Yao, Jianguo Yang   +5 more
doaj   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Magnetostratigraphy of the Late Cenozoic sediments of the West Kunlun foreland and its tectonic implications

Dizhi lixue xuebao
Objective  The West Kunlun Orogenic Belt, located on the northwestern margin of the Tibetan Plateau, is a key area for studying the tectonic uplift and expansion of the plateau.
ZHANG Lijuan, ZHANG Zhiliang, REN Zhikun, BAO Guodong, NING Yutao   +4 more
doaj   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Late Pleistocene-Holocene sedimentary evolution in the coastal zone of the Red River Delta. [PDF]

Heliyon, 2021
Yen HPH, Nhan TTT, Nghi T, Toan NQ, Khien HA, Lam DD, Van Long H, Thanh DX, Hung NT, Trang NTH, Dien TN, Tuyen NT, Truong TX, Dung TT, Thao NTP, Lan VQ.   +15 more
europepmc   +1 more source