Results 61 to 70 of about 48,160 (263)

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Study of Sedimentation Stability of Magnetorheological Fluid [PDF]

Advances in Materials, 2015
Magnetorheological fluid settlement issue has been one of the major issues that affect the performance of the magnetorheological fluid, it was focused by major enterprise and research institutions as new intelligent materials. This paper describes the settlement issue and analyses the reasons that causing settling of MRF at zero field strength.
openaire   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

EFFECT OF VARIOUS SURFACTANTS ON THE STABILITY OF HYBRID NANOFLUIDS: AN EXPERIMENTAL STUDY

Zanco Journal of Pure and Applied Sciences
The most common approach to evaluating the stability of nanofluids is sedimentation analysis; however, further research is needed to confirm stability and determine optimal operating conditions for various nanofluid compositions.
Zhyan Faeaq Hassa, Ahmed Mohammed Adham, Reenas Oraha Canoon Sher   +2 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Magnetorheological Fluid Preparation Using Various Carriers and Study of Their Properties with Decent Durability

Journal of Advanced Engineering and Computation
Sedimentation instability is a significant problem of magnetorheological fluid.   In most situations, the use of different surfactants to coat iron powder is inadequate in maintaining a stable fluid and often leads to sedimentation within a few days. One
Syed Munimus Salam, Muhammad Mahbubur Rashid   +1 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Modeling and optimization of thermal conductivity of stabilized γ-Al2O3 /water nanofluid using response surface methodology (RSM) [PDF]

Journal of Chemical and Petroleum Engineering
The present study estimates thermal conductivity ratio (KR) of stabilized γ-Al2O3 /water nanofluid by response surface methodology (RSM). This study was operated under experimental conditions with solid volume fractions of SVF=0.05–2%, and temperature of
Behrouz Raei
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Storage Stability of Bimodal Emulsions vs. Monomodal Emulsions

Applied Sciences, 2017
Storage stability is a very important parameter that has to be considered in the formulation of asphalt emulsions. When monomodal emulsions are formulated, Stokes’ law is fulfilled, therefore the higher the viscosity the less sedimentation, or the lower ...
Nuria Querol, Camila Barreneche, Luisa F. Cabeza   +2 more
doaj   +1 more source