Results 71 to 80 of about 48,160 (263)

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Functional Properties of Casein Added with Catechin Extracted from Cocoa Husk

Jurnal Ilmu dan Teknologi Hasil Ternak, 2019
Casein is one of the major protein components in milk. Its functional properties allow casein to be preferred by the consumers. In addition, casein could be collected as bioactive compositions to be added to food. The purpose of this study was to observe
Premy Puspitawati Rahayu, Djalal Rosyidi, Purwadi Purwadi, Imam Thohari   +3 more
doaj   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

Hanford contaminated sediment stabilization studies [PDF]

, 1977
The major problems with radionuclide waste sites in the 200 Area plateau on the Hanford Reservation is the high degree of toxicity or Hazard Index (HI). Transport Factors (TF) are fortunately low but can increase with time and certainly with episodic events such as explosions or earthquakes.
Bruns, L.E., Key, K.T., Higley, B.A.
openaire   +2 more sources

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

D.3.6 – Sediment Dynamics And Stability

, 2017
The objective of the FAST project is to develop a Copernicus downstream service based on (Sentinel) satellite data and in situ data to assess the function of wetlands in reducing flood risk and erosion. This requires an assessment of the erodibility and stability of foreshores, as well as knowledge on how saltmarshes function and develop, in order to ...
van der Wal, Daphne, Evans, Ben R., Willemsen, Pim W.J.M., Morris, Edward P., Bouma, Tjeerd J.   +4 more
openaire   +2 more sources

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Influence and Kinetic Study of Mango Peel Pectin with Different Esterification Degrees on the Stability of Mango Juice

Shipin gongye ke-ji
Pectin was extracted from the peels of Tainong No.1 mango via ultrasound-assisted acid hydrolysis, and four types of pectins with different degrees of esterification (DE) were prepared by alkaline deesterification, namely DEMP1, DEMP2, DEMP3, and DEMP4 ...
Ya LI, Xixiang SHUAI, Ming ZHANG, Liqing DU, Lingdong LI, Yuhan ZHANG, Xinchuan ZHONG, Xinrui PAN   +7 more
doaj   +1 more source