Results 81 to 90 of about 249,220 (266)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Looking for biomarkers of Hg exposure by transcriptome analysis in the aquatic plant Elodea nuttallii

open access: yesE3S Web of Conferences, 2013
Recently developed genomics tools have a promising potential to identify early biomarkers of exposure to toxicants. In the present work we used transcriptome analysis (RNA-seq) of Elodea nuttallii –an invasive rooted macrophyte that is able to accumulate
Regier N.   +4 more
doaj   +1 more source

Concentration, enrichment and distribution of heavy metals in surface sediments of the Tangier Bay, Morocco

open access: yesScientia Marina, 2010
The distribution, enrichment, and accumulation of heavy metals in the surface sediments of the Tangier Bay, Morocco, were investigated. Surface sediment samples from eleven locations in the Bay of Tangier were collected in 2007 and characterized for ...
María Rocío Rodríguez-Barroso   +4 more
doaj   +1 more source

Natural and anthropogenic lead in sediments of the Rotorua lakes, New Zealand

open access: yes, 2010
Global atmospheric sources of lead have increased more than 100-fold over the past century as a result of deforestation, coal combustion, ore smelting and leaded petroleum. Lead compounds generally accumulate in depositional areas across the globe where,
Hendy, Chris H.   +7 more
core   +1 more source

2-D optical quantification of particle reworking activities in marine surface sediments [PDF]

open access: yes, 2003
Particle and solute transport by faunal activities may significantly influence rates and pathways of organic matter mineralization during early diagenesis in surface sediments. One of the most frequently utilized techniques to quantify benthic biological
Strömberg, Niklas   +4 more
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Intrinsic and scattering attenuations of the Sichuan-Yunnan region in China from S coda wavesKey points

open access: yesEarthquake Science
Seismic attenuation is a fundamental property of the Earth's media. Attenuation structure for the complicated geological structures with strong seismicity in the Sichuan-Yunnan region is poorly studied. In this study, we collected 108,399 waveforms of 11,
Tian Li   +6 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Moment magnitude of Myanmar earthquake on March 28, 2025 from long-period seismic codaKey points

open access: yesEarthquake Science
On March 28, 2025, a large earthquake struck central Myanmar and caused massive damage and casualties. The magnitude of the mainshock is a fundamental parameter that both the general public and scientific communities are concerned about.
Tian Li, Xiaodong Song
doaj   +1 more source

Modeling and interpreting element ratios in water and sediments: A sensitivity analysis of post-Chernobyl Ru : Cs ratios. [PDF]

open access: yes, 1995
When elements are simultaneously added to lakes, experimentally or by accident, their ratios in the water phase and in bottom sediments can change with time due to differential partitioning between solution and suspended particles or sediments.
Hamilton-Taylor, J.   +8 more
core  

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