Results 111 to 120 of about 1,948,220 (393)

A review of geophysical studies on the Mongolian Plateau

open access: yesEarthquake Science
The Mongolian Plateau in Central Asia is an intracontinental tectonic system far from active plate boundaries. Despite its distance from these boundaries, the plateau is characterized by intense crustal deformation accompanied by voluminous Cenozoic ...
Lei Zhang   +3 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

Accumulation in bollom sediments and physiological state of the sturgeon of Volga-Caspian basin

open access: yesЮг России: экология, развитие, 2015
There are defined the bottom sediments of the Caspian sea. Heir role in harlot metals accumulation and their impact on physiological state of the sturgeon fish.
V. F. Zaytsev   +4 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Microbial diversity in Baltic Sea sediments [PDF]

open access: yes, 2007
This thesis focuses on microbial community structures and their functions in Baltic Sea sediments. First we investigated the distribution of archaea and bacteria in Baltic Sea sediments along a eutrophication gradient.
Edlund, Anna
core  

Swath Mapping on the Continental Shelf and Slope: The Eel River Basin, Northern California [PDF]

open access: yes, 1996
First Paragraph The STRATAFORM program sponsored by the Office of Naval Research (Nittrouer and Kravitz, 1996, this issue) seeks to understand how sedimentary processes lead to the formation of the stratigraphic sequences on continental margins.
Goff, John A.   +3 more
core   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

First record of trilobites (Arthropoda) from Carboniferous deposits of the Dnipro-Donets Depression, north-eastern Ukraine

open access: yesGeologos
A small trilobite faunule consisting of Weberides mucronatus (M’Coy, 1844) and Waribole sp. is described from Serpukhovian (Upper Mississippian) strata of the Sribne-Krasnograd Zone in the Dnipro-Donets Depression (north-eastern Ukraine).
Dernov Vitaly
doaj   +1 more source

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