Results 111 to 120 of about 2,064,336 (302)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Seed production in cabbage [PDF]
Selekcija i Semenarstvo, 2000 In this region, cabbage has a long tradition of growing and a variety of possible uses. Because of this, high-quality seed production is required. Cabbage is a biennial, open-pollinated crop whose seed production requires the knowledge of certain growing
Červenski Janko, Gvozdenović Đuro
doaj
, 2011 Introduction; Place where the Denia onion is grown; Quality of home grown Denias; Spain produces the Denia onion seed; Growing Denia onion seed 1909-10; Raising Denias from home grown seed; Experiments in the Pecos Valley; Growing Denia onion seed 1910 ...
García, Fabián;
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Soil seed bank dynamics in Mediterranean urban vegetation fragments
, 2012 Conservation of biodiversity in urban vegetation fragments is of increasingly high importance with growing urbanisation globally, particularly so in the biodiversity hotspot of the Mediterranean southwest of Western Australia.
Davis, Jessica
core
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Key Priorities for Intervention in Uganda’s Seed Industry [PDF]
, 2018 A competitive seed sector is key to ensuring timely availability of high quality seeds of improved varieties at affordable prices to smallholder farmers in Uganda.
African Seed Access Index
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Assessing the Genotypic Differences for Seed Set and Seed Abortion in Tomato Genotypes
, 2009 Tomato (_Lycopersicon esculentum_ Mill.) is one of the most popular fruit vegetable around the world. Seed abortion where in only a small proportion of ovules in an ovary develops into matured seeds, is a wide spread phenomenon in multi-ovulated species.
Ganeshaiah Narayana +2 more
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source