Results 121 to 130 of about 2,064,336 (302)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

open access: yesMolecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski   +12 more
wiley   +1 more source

UK Flora Protocol for Seed Collection.

open access: yes, 2020
This protocol has been compiled to provide information and advice for those proposing to participate in seed collecting in the UK for the Royal Botanic Gardens Kew (RBG Kew) Millennium Seed Bank ...
Millennium Seed Bank Partnership
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In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Iowa Seed & Biosafety News (Vol. 22, No. 1)

open access: yes, 2005
Contents: Why BIGMAP?; Seed Science Center and BIGMAP profiles; Harmonization of seed policies and regulation in South America; Biotechnology opportunities for small markets; BIGMAP and biopharma: first study products are emerging; Growing transgenic and

core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Control of seed-borne pathogens on vegetables by microbial and other alternative seed treatments

open access: yes, 2004
In the EU-project "Seed Treatments for Organic Vegetable Production" (STOVE) physical and biologfoal methods aimed at the control of seed-borne vegetable pathogens are being investigated.
Koch, Eckhard   +8 more
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Growing up in Ireland. Key findings: infant cohort (at 3 years).

open access: yes, 2011
 The latest results from the study paint a picture of how these families are faring across a range of areas in their lives including their health, family life and financial and economic circumstances.
Growing Up in Ireland
core   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach   +9 more
wiley   +1 more source

Charter and by-laws of the Marienfeld Fruit Growing, Gardening and Irrigation Company

open access: yes, 1888
A pamphlet with the charter and bylaws of the Marienfeld Fruit Growing, Gardening and Irrigation ...
Marienfeld Fruit Growing, Gardening and Irrigation Company
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