Results 121 to 130 of about 159,309 (302)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
ALFALFA SEED GROWING AND THE WEATHER, IN UTAH
Monthly Weather Review, 1919 Abstract SYNOPSIS The first crop of alfalfa is usually cut for hay in Utah, and the second crop is allowed to go to seed. The seed crop should have sufficient moisture during its early growth to produce a vigorous, healthy plant, but the weather should be dry and not too warm while the plants are in bloom.
openaire +1 more source
Farm-economics of genetically improved carp strains in major Asian countries and carp seed price policy model [PDF]
The study has conducted the micro level analysis of hatchery operators, fishseed-rearing farmers and carp farmers with respect to their socio-economic characteristics, infrastructural development, husbandry practices and economics returns, based on the ...
Barik, Nagesh K. +2 more
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
SSGA and MSGA: two seed-growing algorithms for constructing collaborative subnetworks. [PDF]
Sci Rep, 2017 Ji X +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Cold crucible Czochralski for solar cells [PDF]
The efficiency and radiation resistance of present silicon solar cells are a function of the oxygen and carbon impurities and the boron doping used to provide the proper resistivity material.
Trumble, T. M.
core +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
THE CONSEQUENCES OF AN OPEN FIELD BURNING BAN ON THE U.S. KENTUCKY BLUEGRASS SEED INDUSTRY [PDF]
An econometric model of the U.S. Kentucky bluegrass seed industry in the Pacific Northwest is specified and estimated in order to evaluate the short and long run consequences of yield reductions associated with a ban on open field burning of grass ...
Burt, Lawrence A. +2 more
core +1 more source