Results 91 to 100 of about 1,263,730 (307)

Efficient nearly orthogonal and space-filling Latin hypercubes [PDF]

, 2007
SEED Center ...
Cioppa, T.M., T.W. Lucas
core   +1 more source

A multi-resolution systematically improvable quantum embedding scheme for large-scale surface chemistry calculations

Nature Communications
Predictive simulation of surface chemistry is critical in fields from catalysis to electrochemistry and clean energy generation. Ab-initio quantum many-body methods should offer deep insights into these systems at the electronic level but are limited by ...
Zigeng Huang, Zhen Guo, Changsu Cao, Hung Q. Pham, Xuelan Wen, George H. Booth, Ji Chen, Dingshun Lv   +7 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Battling Phages: How Bacteria Defend against Viral Attack. [PDF]

PLoS Pathogens, 2015
Kimberley D Seed
doaj   +1 more source

Seed transmission of Carlavirus vignae (Cowpea mild mottle virus): a hidden driver of veinal necrosis and bud blight disease in soybean (Glycine max) in India

Frontiers in Microbiology
A comprehensive investigation was conducted to determine the seed transmission potential of cowpea mild mottle virus (CPMMV) associated with veinal necrosis and bud blight (VNB) disease in soybean (Glycine max) under Indian agroecological conditions ...
Dhruva Nitin Bhagwatkar, Nagamani Sandra, Ankita Tripathi, Garima Dalal, Sharankumar Kesaratagi, Manisha Saini, Sandeep Kumar Lal, Sanjay Kumar Lal   +7 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

X-ray densitometry to assess internal seed morphology and quality

, 2012
Non-destructive procedures are desirable for a precise internal seed morphology assessment. In this research the efficiency of X-ray densitometry for internal seed morphology analysis and physical quality of squash, melon and watermelon was evaluated ...
Júnior, Francisco Guilhien Gomes, Yagushi, Juliana Tieme, Belini, Ugo Leandro, Cicero, Silvio Moure, Filho, Mario Tomazello   +4 more
core  

Very large fractional factorials and central composite designs [PDF]

, 2005
SEED Center ...
Sanchez, Susan M., Sanchez, Paul J., Sanchez, S.M., Sanchez, P.J.   +3 more
core   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source