Results 81 to 90 of about 2,153,562 (358)

Exploring selection signatures in the divergence and evolution of lipid droplet (LD) associated genes in major oilseed crops

BMC Genomics
Background Oil bodies or lipid droplets (LDs) in the cytosol are the subcellular storage compartments of seeds and the sites of lipid metabolism providing energy to the germinating seeds.
Ramya Parakkunnel, Bhojaraja Naik K, Girimalla Vanishree, Anjitha George, Sripathy KV, Aruna YR, Udaya Bhaskar K, A Anandan, Sanjay Kumar   +8 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Evaluation of production systems for sustainable coriander and coriander-cabbage intercropping system in the semi-arid region of India

Discover Sustainability
Coriander (Coriandrum sativum L.) is an important seed spice crop widely grown for its culinary, medicinal, and industrial value. However, its productivity and quality are often inadequate due to poor nutrient management practices and declining soil ...
Shiv Lal, Gopal Lal, Narottam Kumar Meena, Narendra Chaudhary, Chetan Kumar Jangid, Mahesh Kumar Mahatma, Ram Dayal Meena, Murlidhar Meena, Sanjay Kumar, Kailashpati Tripathi, Sumer Singh Meena, Monika Choudhary, Vinay Bhardwaj   +12 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Wheat and barley seed system in Syria: farmers' varietal perceptions, seed sources and seed management

, 2011
A total of 206 wheat and 200 barley farmers were interviewed in northeastern Syria to understand farmer perceptions and practice relating to modern varieties, seed sources and seed quality. Wheat farmers had better awareness and grew modern varieties (87%
Gastel, A.J.G., van, Struik, P.C., Bishaw, Z.   +2 more
core  

Seed identification using a computerised database

, 2005
Seed testing laboratories worldwide analyse samples for quarantine assessments to prevent the entry of prohibited and restricted seeds. Current practices of identifying seeds by comparing an unknown seed with samples of known seeds or photographs of ...
Basnet, Badri Bahadur, Gupta, Madan, George, Doug   +2 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

The inclusion of students with visual impairments in the school context

Estação Científica, 2017
This work addresses the inclusion of students with visual impairments in the process of teaching and learning. The objective is to analyze the existing literature and public policies directed to this issue, as well as promoting the importance of ...
Ana Cleia da Luz Lacerda Sousa, Ivaldo Silva Sousa   +1 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source