Results 61 to 70 of about 545,587 (268)

The inclusion of students with visual impairments in the school context

open access: yesEstação Científica, 2017
This work addresses the inclusion of students with visual impairments in the process of teaching and learning. The objective is to analyze the existing literature and public policies directed to this issue, as well as promoting the importance of ...
Ana Cleia da Luz Lacerda Sousa   +1 more
doaj   +1 more source

IMPROVEMENT OF QUALITY OF SEEDING OF SEEDS OF SMALL SEED CROPS

open access: yesVESTNIK RIAZANSKOGO GOSUDARSTVENNOGO AGROTEHNOLOGICHESKOGO UNIVERSITETA IM P A KOSTYCHEVA, 2020
Мелкосеменные культуры, такие как люцерна, клевер, рапс являются прекрасными кормовыми культурами и предшественниками для сельскохозяйственного производства. Нельзя забывать и о том, что из семян некоторых мелкосеменных культур производят альтернативные виды топлива, что весьма актуально при снижении мировых запасов углеводородов.
openaire   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Sucrase in immobilized cells of Cucumis sativus L.

open access: yesHorticultural Science, 2002
Cell suspension cultures of Cucumis sativus L. - cucumber were permeabilized by Tween, hexadecyltri-methylammonium bromide, hexadecylpyridiniumbromide ethanol and/or immobilized by glutaraldehyde.
S.I. Ignatova   +5 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

A multi-resolution systematically improvable quantum embedding scheme for large-scale surface chemistry calculations

open access: yesNature Communications
Predictive simulation of surface chemistry is critical in fields from catalysis to electrochemistry and clean energy generation. Ab-initio quantum many-body methods should offer deep insights into these systems at the electronic level but are limited by ...
Zigeng Huang   +7 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Seed transmission of Carlavirus vignae (Cowpea mild mottle virus): a hidden driver of veinal necrosis and bud blight disease in soybean (Glycine max) in India

open access: yesFrontiers in Microbiology
A comprehensive investigation was conducted to determine the seed transmission potential of cowpea mild mottle virus (CPMMV) associated with veinal necrosis and bud blight (VNB) disease in soybean (Glycine max) under Indian agroecological conditions ...
Dhruva Nitin Bhagwatkar   +7 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Home - About - Disclaimer - Privacy