Results 141 to 150 of about 37,640 (261)

A Phase‐Resolved Geometric Deep Learning Framework Maps Structural Determinants of Disease‐Associated Protein Aggregation and Guides Suppressor Design

Advanced Science, EarlyView.
SKALE 2.0 maps disease‐associated protein aggregation as a phase‐resolved structural process, linking mutation‐induced geometric perturbations to nucleation, elongation, and suppressor design. Across neurodegenerative proteins, the framework reveals cryptic aggregation vulnerabilities, separates phase‐concordant and phase‐switching mutations, and ...
Jia Shen Sio, Wei Xuan Wilson Loo, Yan Shan Loo, Wen Xin Tan, Hui Xuan Lim, Huitao Liu, Chen Seng Ng   +6 more
wiley   +1 more source

Phylogenomic Barcoding of Soil Seed Bank-Persistent and Wind-Dispersed Non-Native Plant Species in South Georgia. [PDF]

Mol Ecol Resour
Viruel J, Sweeney CJ, Day R, White K, Dawson W, Myer B, Floyd K, Corcoran M, Kelting C, Poncet S, Forest F, Clubbe C, Newton RJ.   +12 more
europepmc   +1 more source

Separation of timescales for the seed bank diffusion and its jump-diffusion limit. [PDF]

J Math Biol, 2021
Blath J, Buzzoni E, González Casanova A, Wilke Berenguer M.   +3 more
europepmc   +1 more source

Inhibition of KDEL Receptors Remodels the Tumor Microenvironment for T Cell Independent Tumor Regression

Advanced Science, EarlyView.
Inhibition of KDELR2 in a small fraction of tumor cells generates sustainable immunogenic cell death conditions within the tumor microenvironment. These conditions promote the regression of tumors in a T cell independent manner. During regression, macrophages prime T cells that subsequently provide systemic protection against recurrence. The potency of
Shakti P Pattanayak, Hong Wang, Belinda Willard, Timothy A. Chan, William C Merrick, Zheng‐Rong Lu, Boaz Tirosh   +6 more
wiley   +1 more source

Looking back to look ahead: the temporal dimension of conservation seed bank collections. [PDF]

New Phytol
Mattana E, Godefroid S, Miles S, Carta A, Ensslin A, Chapman T, Viruel J.   +6 more
europepmc   +1 more source

A century-long record of plant evolution reconstructed from a coastal marsh seed bank. [PDF]

Evol Lett, 2021
Blum MJ, Saunders CJ, McLachlan JS, Summers J, Craft C, Herrick JD.   +5 more
europepmc   +1 more source

Radiation‐Induced Tumor‐Intrinsic LTβR N‐Glycosylation Suppresses Pyroptosis Through TRIM28‐Mediated PCBP2 SUMOylation to Promote Gastric Cancer Radioresistance

Advanced Science, EarlyView.
Radiotherapy triggers LTβR N‐glycosylation, enhancing its overall protein stability and nuclear retention. This accumulation drives TRIM28‐mediated PCBP2 SUMOylation, suppressing pyroptosis and conferring gastric cancer radioresistance. Therapeutically, a targeted nanoplatform (cRGD‐Lipo@EMD) effectively disrupts this regulatory axis, offering a highly
Weijie Zang, Yunlong Ji, Chunwang Zhou, Xiwen Li, Zhuang Lu, Guangze Zhang, Yu Chen, Wanjiang Xue, Yilin Hu   +8 more
wiley   +1 more source

Response of the germinable soil seed bank of temperate Leymus chinensis meadows to mowing regimes. [PDF]

Front Plant Sci
Zhang Z, Yu T, Xin X, Liu H, Lv S, Wei Z, Han G, Yan R.   +7 more
europepmc   +1 more source

Comparative whole-genome and proteomics analyses of the next seed bank and the original master seed bank of MucoRice-CTB 51A line, a rice-based oral cholera vaccine. [PDF]

BMC Genomics, 2021
Sasou A, Yuki Y, Honma A, Sugiura K, Kashima K, Kozuka-Hata H, Nojima M, Oyama M, Kurokawa S, Maruyama S, Kuroda M, Tanoue S, Takamatsu N, Fujihashi K, Goto E, Kiyono H.   +15 more
europepmc   +1 more source

Targeting the HSPA8‐CMA‐ATP6V1A Axis Triggers Lysosomal Hyperacidification and Catastrophic Vacuolation in Prostate Cancer

Advanced Science, EarlyView.
Our experimental evidence supports a model in which ALO targets the HSPA8‐CMA‐ATP6V1A axis to induce lysosomal hyperacidification and initiate osmotic and lipidomic stress. These changes are associated with LMP and loss of lysosomal integrity in prostate cancer cells.
Bingzheng An, Ze Gao, Shuo Chen, Liwei Meng, Chen Zhang, Kefan Song, Haochen Cui, Lei Yan, Zhiqing Fang   +8 more
wiley   +1 more source