Results 51 to 60 of about 1,016,719 (277)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Effects of seed coating and priming with exogenous brassinosteroid on tobacco seed germination
Journal of Plant InteractionsBrassinosteroid (BR) is a hormone known for its crucial role in seed germination promotion. However, there is a limited understanding of potential application in tobacco seed.
Guoping Wang +5 more
doaj +1 more source
Materials Research Express, 2022 Branches of ZnO nanostructure were hydrothermally grown on seed layer coated on sub-microrod template by ultrasonic-assisted immersion technique. Zinc acetate, monoethanolamine, and isopropanol were used as a precursor, stabilizer, and solvent for ...
Nontakoch Siriphongsapak +1 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Seed coat development in Velloziaceae: Primary homology assessment and insights on seed coat evolution [PDF]
American Journal of Botany, 2014 • Premise of the study: Seed coat characteristics have historically been used to infer taxonomic relationships and are a potential source of characters for phylogenetic reconstruction. In particular, seed coat morphoanatomy has never been studied in detail in Velloziaceae. One character based on seed surface microsculpture has been used in phylogenies,
Mariane S, Sousa-Baena +1 more
openaire +2 more sources
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Agronomy, 2019 In order to reduce the usage amount of pesticide fertilizers and protect the natural environment, seed coating agents are receiving increased wide concern.
Xue-Xiang Ren +6 more
doaj +1 more source
The Rôle of the Seed-coat in Relation to the Germination of Immature Seed
Annals of Botany, 1920 (Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
Kidd, Franklin, West, Cyril
openaire +3 more sources
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source