Results 131 to 140 of about 2,366,545 (259)

Magnetoreceptor Promotes Hepatocellular Carcinoma Development and Blunts Sorafenib‐Induced Ferroptosis by Regulating Iron Homeostasis

Advanced Science, EarlyView.
Magnetoreceptor (MagR) regulates iron homeostasis and mitochondrial function in hepatocellular carcinoma (HCC) cells. Specifically, MagR deficiency suppresses tumor cell proliferation, migration, and invasion and enhances sorafenib‐induced ferroptosis through iron accumulation.
Tao Wang, Chenghua Song, Xin He, Mengzhou Wang, Wuming Liu, Xiaolin Wang, Yuanyuan Zhang, Jia Zhang, Lin Zhang, Dan Li, Yu Zhang, Zheng Wu, Yi Lyu, Rongqian Wu   +13 more
wiley   +1 more source

A Spatiotemporal Single‐Cell Atlas Uncovers Dysregulated ECM Dynamics and Septal Remodeling Arrest in Human Ventricular Septal Defects

Advanced Science, EarlyView.
Integrating single‐cell and spatial transcriptomics reveals human ventricular septal defect (VSD) as a disease of microenvironmental insufficiency and structural remodeling arrest. Attenuated endothelial‐fibroblast crosstalk, alongside downregulated THBS1/TGF‐β1 and MMP2 signaling networks, impairs the endothelial‐to‐mesenchymal transition (EndoMT) and
Xiaoyuan Zhang, Lun Zhu, Ze Sun, Ruolin Jia, Ziming Wang, Jiayao Zhao, Bohao Liu, Haiqing Xiong, Xiaowei Yu, Yanzhu Yue   +9 more
wiley   +1 more source

Metabolic Signatures for Liver Cancer Diagnosis and Mechanistic Insights: A Large‐Scale, Multicenter Study

Advanced Science, EarlyView.
A large‐scale multicenter serum metabolomics study (13 centers, n = 2,149) identified a 9‐metabolite + AFP diagnostic signature for liver cancer (AUC = 0.93). Among the signature, nicotinamide (NAM) was validated as an oncometabolite: NAM enhances NAD+ synthesis, activating SIRT1 to deacetylate and stabilize HIF1α, thereby driving glycolysis, MAPK ...
Yongjie Xu, Jiachen Wang, Chunmeng Ding, Changfa Xia, Yunyong Liu, Yuanjie Zheng, Sheng Chang, Shaokai Zhang, Yutong He, Ruifang Sun, Yunfeng Xi, Yan Liu, Kun Qian, Wanqing Chen   +13 more
wiley   +1 more source

Understanding the impact of Cotton Subsidies on developing countries [PDF]

Models developed to investigate the impact of cotton subsidies have found that US support, by virtue of its absolute magnitude, is particularly damaging and responsible for most of the reduction in cotton-earning potential in developing countries.
Page, S, Balcombe, Kelvin, Poulton, Colin, Gillson, I   +3 more
core  

An Adenoviral‐Vectored Tp0326 Vaccine Elicits Robust Functional Antibodies to Prevent Treponema pallidum Dissemination in a Rabbit Model

Advanced Science, EarlyView.
Vaccination promotes cellular infiltration into primary lesions and effectively inhibits T. pallidum dissemination to distal organs. Notably, transfer of lesion tissue from immunized animals fails to establish infection in naive recipients, confirming specific protective immunity.
Yinbo Jiang, Xinyuan Li, Lixia Huang, Xiangcai Zhang, Wujian Ke   +4 more
wiley   +1 more source

Character association and Path analysis of some Quantitative and Qualitative traits among interspecific crosses of Gossypium arboreum and Gossypium herbaceum [PDF]

Electronic Journal of Plant Breeding, 2011
Studies on correlation indicated that intensive selection on the positive side for plant height, sympodia per plant, seed index, lintindex, 2.5 per cent span length and bolls per plant since these characters showed positive correlation with seed cotton ...
S.Saravanan and K. Koodalingam
doaj  

Heterosis for seed cotton yield and its contributing characters in cotton (GossypiumhirsutumL.)

Electronic Journal of Plant Breeding, 2014
A line x tester crossing programme was taken up with ten lines and five testers with a view to identify the best heterotic crosses for seed cotton yield and its attributing traits in upland cotton. The analysis of variance revealed significant differences among genotypes, parents, hybrids and parents Vs hybrids for all the eight traits except parents ...
openaire   +1 more source

LEADING INDICATORS FOR REGIONAL COTTON RESPONSE: STRUCTURAL AND TIME SERIES MODELING RESULTS [PDF]

Resurging southeastern cotton production compels better cotton acreage forecasts for planning seed, chemical, and other input requirements. Structural models describe leading acreage response indicators, and forecasts are compared time-series models ...
Houston, Jack E., Stavriotis, Paul A., McIntosh, Christopher S., Turner, Steven C.   +3 more
core  

A ROS‐Responsive and Mucoadhesive Thermosensitive Hydrogel Encapsulated with Mizoribine for Synergistic Dry Eye Therapy

Advanced Science, EarlyView.
The ROS‐responsive in situ thermosensitive MZR@SPPP hydrogel system enables dual‐stage drug loading and sustained ocular delivery. Upon administration, it gelates at ocular surface temperature, enhancing ocular adhesion. By scavenging free radicals, restoring NRF2‐mediated antioxidant defense and mitochondrial homeostasis, and suppressing inflammatory ...
Danyi Qin, Jiani Li, Panqin Ma, Shinan Wu, Wenying Guan, Yimin Huang, Ke Feng, Mingyan Wei, Zixuan Yang, Shujia Guo, Caihong Huang, Yun‐Long Wu, Yi Han, Zuguo Liu   +13 more
wiley   +1 more source

Combining ability and heterosis studies for seed cotton yield and fibre quality traits in hirsutum cotton

Electronic Journal of Plant Breeding
Fifty intra hirsutum hybrids developed by involving five female and ten testers were evaluated to study gene action, combining ability and heterosis. The analysis of variance indicated substantial variability among the experimental material for yield, its contributing components and fibre quality traits.
null M. Gnanasekaran, null K. Thiyagu, null M. Gunasekaran   +2 more
openaire   +2 more sources