Results 141 to 150 of about 208,285 (263)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

What happens to the soil seed bank 17 years after clear cutting of vegetations?

open access: yesRevista de Biología Tropical, 2015
Seed banks play an important role in the resilience of potential anthropogenic areas and are influenced by seasonal variation. The spatial and temporal heterogeneity of the forests influences the richness and density of the soil seed bank, but there is a
Leonardo Brasil Mendes   +5 more
doaj  

Activation of seed-specific genes in leaves and roots of the desiccation tolerant plant, Xerophyta humilis

open access: yes, 2008
Includes abstract.Includes bibliographical references (leaves 131-169).The ability of tissues to survive almost complete loss of cellular water is a trait found throughout the plant kingdom.
Walford, Sally-Ann
core  

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

open access: yesFEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour   +2 more
wiley   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

open access: yesFEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar   +4 more
wiley   +1 more source

Improving Groundcover Establishment Through Seed Rate, Seed Ratio, and Hydrophilic Seed Coating

open access: yes
Kentucky bluegrass (KBG) is well-suited as a perennial groundcover in corn production due to its vigorous growth during the fall and spring and its natural dormancy during the summer, aligning with the corn growing season. However, seeds of KBG germinate
Moore, Ken   +4 more
core  

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

open access: yesFEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai   +8 more
wiley   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

open access: yesFEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão   +3 more
wiley   +1 more source

Small RNA pathways in mammalian oocytes

open access: yesFEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Importance of stand density, inter row spacing, "mother" and "father" row distance in corn seed production

open access: yes, 2006
Importance of stand density, "mother" and "father" row distance is very important for corn seed production. Inter row spacing from 70,60 and 50 cm, and their influence on "mother" grain yield was investigated during 7 years trials. In seed production, at
Marinković Branko, Crnobarac Jovan
core  

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