Results 61 to 70 of about 208,285 (263)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
PLoS ONE, 2012 Studies on the importance of seed arrival for community richness and composition have not considered the number of seeds arriving and its effect on species richness and composition of natural communities is thus unknown.
Zuzana Münzbergová
doaj +1 more source
INFLUENCE OF VERMICOMPOST AND PLANT DENSITY ON GROWTH AND SEED YIELD OF CORIANDER [PDF]
, 2020 A Thesis Submitted to the Institute of Seed Technology, Sher-e-Bangla Agricultural University, Dhaka in partial fulfillment of the requirements for the degree of
HOSSAIN, MD. FOYSAL
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Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
The impact of herbivores on the natural regeneration of temperate deciduous woodland [PDF]
, 1999 Many studies have reported deficient or intermittent patterns of natural regeneration in temperate deciduous woodland. The present study aimed to assess the relative impact of herbivore-mediated plant mortality on the natural regeneration dynamics of ...
Mallinson, Julian Robert
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Effects of plant density on seed yield in Caucasian clover (Trifolium ambiguum Bieb.) cv. Monaro
, 1999 A radial trial design was used to determine the effect of plant density on seed yield of Caucasian clover (Trifolium ambiguum Bieb.) cv. Monaro, and the seed yield response of twelve genotypes selected from within cv. Monaro.
Fu, SM, Hill, MJ, Hampton, John
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Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source