Results 91 to 100 of about 356,668 (268)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Climate Change Mitigation Perspectives from Sub-Saharan Africa: The Technical Pathways to Deep Decarbonization at the City Level

Atmosphere
The complex and multidimensional effect of climate change, coupled with low socioeconomic development, in Sub-Saharan Africa (SSA) makes the region vulnerable to the changing climate and threatens its inhabitants’ survival, livelihood, and health ...
Bayode Akomolafe, Amelia Clarke, Raphael Ayambire   +2 more
doaj   +1 more source

Cytokinins and their function in developing seeds.

Acta chimica Slovenica, 2010
Cytokinins are a major group of plant hormones that control various processes in plant growth and development. Chemically they are N6-substituated adenine derivatives, including their respective ribotides, ribosides and glucosides. The inter-conversion between different cytokinins metabolites represents the transition between active, inactive, storage ...
Dermastia, Marina, Rijavec, Tomaž
openaire   +2 more sources

Environmental Effects on Seed Development and Seed Quality

HortScience, 1980
Abstract The concentration of seed production for some crops in specific areas of the U.S. and of other countries is persuasive testimony of the influence of environmental factors on seed development and quality. The environmental factors that have contributed to the selection and establishment of these specialized seed production ...
openaire   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Player versus Player: A systematic review of cyberbullying in multiplayer online games

Computers in Human Behavior Reports
Introduction: This systematic review evaluates the prevalence, characteristics, and predictors of cyberbullying behaviour in multiplayer online games. Methods: Following the PRISMA framework, seven databases were searched from inception until August 24th,
Hu Yunhao, Evelyn Sophie, Clancy Elizabeth M., Klettke Bianca   +3 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Untargeted Metabolomics Analysis Reveals Differential Accumulation of Flavonoids Between Yellow-Seeded and Black-Seeded Rapeseed Varieties

Plants
Rapeseed (Brassica napus) is an important oilseed crop and yellow-seeded and black-seeded varieties have different metabolite profiles, which determines the quality and edibility of their oil.
Shulin Shen, Yunshan Tang, Daiqin Liu, Lulu Chen, Yi Zhang, Kaijie Ye, Fujun Sun, Xingzhi Wei, Hai Du, Huiyan Zhao, Jiana Li, Cunmin Qu, Nengwen Yin   +12 more
doaj   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source