Results 81 to 90 of about 1,331,739 (313)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Environmental Research CommunicationsAs the global temperature continues to rise each year, limiting global warming to 1.5 °C is increasingly becoming a challenge due to the shrinking size of the remaining carbon budget.
Syeda Tasnia Hasan +4 more
doaj +1 more source
The role of sugars and sugar metabolism genes (sucrose synthase) in arabidopsis thaliana seed development [PDF]
Seed development in Arabidopsis thaliana, has been studied at several levels. However, little has been done to study the role of sugar metabolism genes in seed pod development in this species. As the fertilized egg progresses to a mature seed, the sugars
Odunlami, Benjamin Oladipo
core
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Danger ahead! How Canadians respond to information about the risks of eating meat
Frontiers in Sustainable Food SystemsPrevious research has demonstrated that animal-based diets are harmful to planetary and human health, accounting for a significant portion of global greenhouse gas emissions and increasing the risk of non-communicable diseases.
Rebecca E. Pottage +2 more
doaj +1 more source
Increasing Seed System Efficiency in Africa: Concepts, Strategies and Issues [PDF]
The purpose of this paper is to provide a conceptual framework that can be used by agricultural leaders, administrators, policy makers, and seed program managers to (1) understand key factors affecting seed system development; and (2) compare ...
Boughton, Duncan +5 more
core +1 more source
Breeding initiatives of seeds of landraces, amateur varieties and conservation varieties : an inventory and case studies [PDF]
, 2009 One of the objectives of the Farm Seed Opportunities (FSO) project is to develop on farm breeding methodologies for the conservation and development of landraces, amateur and conservation varieties.
Chable, V., Osman, A.M.
core +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source