Results 121 to 130 of about 191,731 (311)

Seed Pathology: Challenges and Advances in Ensuring a Safe Global Seed Supply

open access: yesAnnual Review of Phytopathology
Seeds are the cornerstone of food security for a growing global population. An ample supply of healthy, high-quality seeds of improved crop varieties is crucial to human nutrition and health. To meet this need, the global seed industry has become increasingly complex, characterized by multinational operations speeding the development of new varieties ...
Gary Munkvold   +2 more
openaire   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

open access: yesFEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan   +6 more
wiley   +1 more source

Fusarium in wheat. Effects of soil fertility strategies and nitrogen levels on mycotoxins and seedling blight. [PDF]

open access: yes, 2009
In a two-year field experiment in the Netherlands the relation between three soil fertility strategies, additional nitrogen levels and Fusarium Head Blight in wheat are explored. There was a substantial year-effect, as could be expected.
Timmermans, Dr. B.G.H.   +1 more
core   +1 more source

CIDI-Lung-Seg: A Single-Click Annotation Tool for Automatic Delineation of Lungs from CT Scans

open access: yes, 2014
Accurate and fast extraction of lung volumes from computed tomography (CT) scans remains in a great demand in the clinical environment because the available methods fail to provide a generic solution due to wide anatomical variations of lungs and ...
Bagci, Ulas   +7 more
core   +1 more source

Calcium‐sensing receptor induces the apoptosis of chondrocytes in cooperation with phosphate transporter

open access: yesFEBS Open Bio, EarlyView.
Excess Ca2+ ions activate the Calcium‐Sensing Receptor (CaSR), which subsequently drives the uptake of excess inorganic phosphate (Pi) via the Pi transporter (Pit−1) in chondrocytes. This mechanism causes a toxic increase in intracellular Pi concentration, ultimately leading to chondrocyte apoptosis and pathological mineralization. Excess extracellular
Sachie Nakatani   +7 more
wiley   +1 more source

Control of common scab without the use of water [PDF]

open access: yes, 2006
The most effective way to control common scab is by irrigating a potato crop at tuber initiation. With the introduction of legislation such as the Water Framework Directive this will become increasingly difficult.
Hilton, A J, Wale, S J, Walker, R L
core  

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

open access: yesFEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang   +7 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Transmissão e patogenicidade de Phomopsis sp. associadas às sementes de angico-vermelho (Parapiptadenia rigida Benth.)

open access: yesFloresta e Ambiente
O estudo da associação de fungos com sementes pode gerar informações importantes, pois alguns desses microrganismos podem causar danos às sementes, além de afetar a produção de mudas.
Clair Walker   +4 more
doaj   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

open access: yesFEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid   +3 more
wiley   +1 more source

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