Results 211 to 220 of about 191,044 (310)

Development of a robust, physiologically relevant neuronal tau aggregation assay for tau-related drug discovery. [PDF]

J Biol Chem
Wu JW, Titterton K, Sebastian R, Romanul N, Yanamandra K, Mastis B, Chang R, Khasnavis S, Kwon T, Chai Y, Manos JD, Preiss CN, Hu M, Welker AM, Liao F, Dellovade T, Karran E, Langlois X.   +17 more
europepmc   +1 more source

Kidney Organoids in Drug Development: Integrating Technological Advances and Standardization for Effective Implementation

Advanced Healthcare Materials, EarlyView.
This review examines how emerging enabling technologies enhance the physiological relevance, scalability, and reproducibility of kidney organoids, while advanced analytical approaches support model validation and deepen mechanistic insight into nephrotoxicity.
Helen Kearney, Silvia M. Mihăilă, Lorenzo Moroni, Carlos Mota   +3 more
wiley   +1 more source

Woody seeds and seedlings are unresponsive to herbivore kairomones. [PDF]

AoB Plants
Headrick KC, Pellegrini BA, Santiago EM, Overstrum KM, Bhavanam SP, Orians CM, Orrock JL, Preisser EL.   +7 more
europepmc   +1 more source

ETV2 Mediated Differentiation of Human Pluripotent Stem Cells Results in Functional Endothelial Cells for Engineering Advanced Vascularized Microphysiological Models

Advanced Healthcare Materials, EarlyView.
A robust method to generate functional human iPSC‐derived endothelial cells using inducible ETV2 expression. These cells self‐organize into stable, lumenized microvascular networks within microfluidic chips, surpassing conventional differentiation methods.
Shun Zhang, Zhengpeng Wan, Lei Wang, Caihong Wu, Junkai Zhang, Sarah Spitz, Xun Wang, Marie A. Floryan, Mark F. Coughlin, Francesca M. Pramotton, Liling Xu, Ron Weiss, Roger D. Kamm   +12 more
wiley   +1 more source

Detection of TDP-43 seeds in CSF of presymptomatic and symptomatic genetic FTD/ALS. [PDF]

Alzheimers Dement
Dellarole IL, Aprea V, Catania M, Battipaglia C, Romeo A, Villa C, Burato A, Celauro L, Bella ED, Riva N, Salvi E, Rossi G, Fede GD, Legname G, De Houwer JFH, Alberici A, Borroni B, Seelaar H, van Swieten JC, Moda F, Caroppo P.   +20 more
europepmc   +1 more source

A Synovium‐on‐Chip Platform to Study Multicellular Interactions in Arthritis

Advanced Healthcare Materials, EarlyView.
The Synovium‐on‐Chip comprises a thin microporous PDMS membrane to support co‐culture of fibroblast‐like synoviocytes (FLS), THP‐1‐derived macrophages, and endothelial cells, enabling real‐time analysis of synovial‐vascular interactions. FLS migration through the pores drives endothelial remodeling, while TNF‐α stimulation induces robust inflammatory ...
Laurens R. Spoelstra, Fleur R. Semmekrot, Nuno Araújo‐Gomes, Daniël Wijnperle, Monique M. A. Helsen, Martijn H.J. Van Den Bosch, Loes. I. Segerink, Séverine Le Gac, Marcel Karperien   +8 more
wiley   +1 more source

A hydroponic system for facilitating observation of plant virus infection in roots. [PDF]

Plant Signal Behav
Chen G, Lei Y, Wang H, Lu Y, Zhou H, Zhao M.   +5 more
europepmc   +1 more source

Low‐Temperature Fabrication of Thymosin β4‐Loaded Soluble Microneedles to Promote Wound Healing by Specific Binding to Downregulated Immune Regulators Vsig4 and IL22rɑ2

Advanced Healthcare Materials, EarlyView.
Schematic diagram depicting the fabrication and application of thymosin β4 (Tβ4)‐loaded microneedle patches for wound treatment. The Tβ4 was loaded into chitosan (CS) and sucrose MNs under mild conditions (4°C, 65% relative humidity). The Tβ4 MN patch specifically binds to the downregulated immune regulators Vsig4 and IL22rα2, thereby accelerating ...
Shilong He, Mei Yuan, Changkang Feng, Yixuan Zhang, Jinjing Che   +4 more
wiley   +1 more source

Effect of tau burden and Lewy pathology on neuropsychiatric symptoms in Aβ-positive individuals. [PDF]

Alzheimers Dement
Kang S, Ye BS, Yun M, Lee YG, Alzheimer's Disease Neuroimaging Initiative.   +4 more
europepmc   +1 more source