Results 51 to 60 of about 192,388 (308)
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Scientia Agricola, 1997 Um produto constituido de pó-molhável (PBBS) formulado à base de células (60g) e de metabólitos (60g) de Bacillus subtilis, argila (480g), espalhante (7,92g) e água (2400ml), moído e seco, mostrou-se semelhante aos tratamentos com fungicidas recomendados
E LAZZARETTI, W BETTIOL
doaj +1 more source
Aggregated Tau activates NLRP3–ASC inflammasome exacerbating exogenously seeded and non-exogenously seeded Tau pathology in vivo [PDF]
Acta Neuropathologica, 2019 Brains of Alzheimer's disease patients are characterized by the presence of amyloid plaques and neurofibrillary tangles, both invariably associated with neuroinflammation. A crucial role for NLRP3-ASC inflammasome [NACHT, LRR and PYD domains-containing protein 3 (NLRP3)-Apoptosis-associated speck-like protein containing a CARD (ASC)] in amyloid-beta ...
Stancu, Ilie-Cosmin +11 more
openaire +4 more sources
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Review on the possible interactions of pests, diseases & weeds in cereals grown in organic and conventional agriculture [PDF]
, 2001 Background The demand for organically produced food is outstripping the ability of UK farmers to supply it and the majority is imported. Furthermore, there is a major shortfall in home-produced organic cereals and cereal products, including straw.
Anon
core
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Arbuscular mycorrhizal fungi [PDF]
, 2005 The potential disease suppressiveness of arbuscular mycorrhizal (AM) fungi of various origins on Bipolaris sorokiniana in barley has been investigated.
Sjöberg, Johanna
core
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Arquivos do Instituto Biológico, 2016 RESUMO: O desenvolvimento de pesticidas é uma constante no setor agropecuário, visando oferecer produtos menos agressivos ao meio ambiente e novos princípios ativos, evitando o aparecimento de resistência.
Maria Paula Domene +4 more
doaj +1 more source