Results 81 to 90 of about 191,044 (310)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Vigorous propagation material and organic breeding in the Netherlands [PDF]

, 2011
Organic cultivation depends on robust and healthy propagation material and the availability of suitable plant varieties. To be able to facilitate organic farmers and growers, Wageningen UR and the Louis Bolk Institute carry out a variety of research ...
Scholten, Olga
core  

Pathotypic diversity of Hyaloperonospora brassicae collected from Brassica oleracea [PDF]

, 2012
Downy mildew caused by Hyaloperonospora brassicae is an economically destructive disease of brassica crops in many growing regions throughout the world.
AA Monteiro, AG Channon, António A. Monteiro, B Agnola, BD Jensen, BM Irish, C Monot, C Sherriff, CE Thomas, CH Dickinson, D Leckie, D Leckie, D Silué, EB Holub, Eric B. Holub, F Delmotte, H Tapsoba, IR Crute, JA Lucas, JC Correll, JG Vicente, JJ Natti, JM Norwood, Joana G. Vicente, JR Greenhalgh, M Göker, M Wang, MH Dickson, MR Armstrong, NA Moss, NA Moss, NA Moss, NI Nashaat, NI Nashaat, P Coelho, Paula S. Coelho, SH Hulbert, T MacGregor, TW Hott, TW Hott, W Shan   +40 more
core   +1 more source

How the shapes of seeds can influence pathology

Neurobiology of Disease, 2018
It is widely accepted that the loss of function of different cellular proteins following their aggregation into highly stable aggregates or the gain of pathologic function of the resulting macromolecular assemblies or both processes are tightly associated to distinct debilitating neurodegenerative diseases such as Alzheimer's, Parkinson's, Creutzfeldt ...
openaire   +3 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Characterising resistance to Turnip mosaic virus (TuMV) in Turnip (Brassica rapa rapa) [PDF]

, 2008
A Brassica rapa rapa L. line has been identified with high resistance to seven isolates of Turnip mosaic virus (TuMV) (including UK 1, CHN 5, CZE 1, CDN 1, GBR 6, POL 1 and UK 4) representing the major pathotypes of the virus.
Haj Kassem, Amin A., Walsh, John A.
core  

Pathological Study of Retinoblastoma treated by Radon Seeds and Radium Disks [PDF]

British Journal of Ophthalmology, 1952
FIRST, I thank you most sincerely for the great honor you have done me in inviting me to give this lecture in memory of the late Charles H. May. Charles H. May came to New York at the age of 4, and in this great city his work as a famous teacher, a skillful surgeon, and a man of absolute integrity of character and high ethical standards justifiably ...
openaire   +4 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Tratamentos osmóticos e térmicos para controle de fungos em sementes de grumixameira (Eugenia brasiliensis Lam.) e pitangueira (Eugenia uniflora L.)

Hoehnea
As sementes de grumixama (Eugenia brasiliensis Lam.) e pitanga (Eugenia uniflora L.) são intolerantes à dessecação e seu elevado teor de água favorece a proliferação de fungos que podem acelerar sua deterioração.
Cibelle Ferreira Françoso, Claudio José Barbedo   +1 more
doaj   +1 more source