Results 71 to 80 of about 282,702 (308)
Evolutionary-thinking in agricultural weed management [PDF]
Agricultural weeds evolve in response to crop cultivation. Nevertheless, the central importance of evolutionary ecology for understanding weed invasion, persistence and management in agroecosystems is not widely acknowledged.
Ainsworth +140 more
core +2 more sources
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Leucojum aestivum is known for its ability to biosynthesize alkaloids with therapeutic properties, among which galanthamine used for the treatment of Alzheimer's disease. New sources of this alkaloid are still being explored.
Agata Ptak +9 more
doaj +1 more source
The growth of plant embryos in vitro. Preliminary experiments on the role of accessory substances [PDF]
The aseptic culture of plant embryos isolated from the seed dates back to the work of Brown and Morris,(1) Hannig(2) and Dietrich.(3) More recent contributions to our knowledge concerning the culture in vitro of excised embryos have been made by Tukey,(4)
Axtman, Grice, Bonner, James
core +1 more source
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Seed dormancy prevents seeds from germinating under environmental conditions unfavourable for plant growth and development and constitutes an evolutionary advantage.
Rueda Romero, Paloma +4 more
core +1 more source
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Plant Pumilio proteins: Parallels and prospects of antagonistic functions in non-plant organisms
Pumilio (PUM) proteins belong to the Puf family of RNA binding proteins that shows very strong conservation across eukaryotes, both structurally and functionally.
Annika Liefferink +2 more
doaj +1 more source
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Crop biotechnology: prospects and opportunities [PDF]
SUMMARYThis paper is a brief review summarizing some of the important areas of activity in crop biotechnology likely to be exploited over the medium term (10–20 years), with an emphasis on agronomic traits.
Dunwell, J. M.
core +1 more source

