Results 81 to 90 of about 282,702 (308)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Growth Performance of Sabia Grass Irrigated by Drippers Installed in Subsurface

AgriEngineering
Studies to improve the use of subsurface drippers in pasture formation are needed. Therefore, the objective of this study was to evaluate the germination and emergence of Sabia grass as a function of drippers installed at different depths.
Mayara Oliveira Rocha, Amilton Gabriel Siqueira de Miranda, Policarpo Aguiar da Silva, Job Teixeira de Oliveira, Fernando França da Cunha   +4 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Redox dynamics in seeds of Acer spp: unraveling adaptation strategies of different seed categories

Frontiers in Plant Science
BackgroundSeeds of woody plant species, such as those in the Acer genus like Norway maple (Acer platanoides L.) and sycamore (Acer pseudoplatanus L.), exhibit unique physiological traits and responses to environmental stress.
Hanna Fuchs, Aleksandra M. Staszak, Paola A. Vargas, Mariam Sahrawy, Antonio J. Serrato, Marcin K. Dyderski, Ewelina A. Klupczyńska, Paweł Głodowicz, Katarzyna Rolle, Ewelina Ratajczak   +9 more
doaj   +1 more source

Environmental, developmental, and genetic factors controlling root system architecture [PDF]

, 2014
A better understanding of the development and architecture of roots is essential to develop strategies to increase crop yield and optimize agricultural land use.
Mansoorkhani, F. M., Moeiniyan Bagheri, H., Ramsey, R. J. L., Seymour, G. B., Swarup, R., Thompson, Andrew J.   +5 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Construction of a High-Density Genetic Map from RNA-Seq Data for an Arabidopsis Bay-0 × Shahdara RIL Population

Frontiers in Genetics, 2017
High-density genetic maps are essential for high resolution mapping of quantitative traits. Here, we present a new genetic map for an Arabidopsis Bayreuth × Shahdara recombinant inbred line (RIL) population, built on RNA-seq data. RNA-seq analysis on 160
Elise A. R. Serin, L. B. Snoek, L. B. Snoek, Harm Nijveen, Harm Nijveen, Leo A. J. Willems, Jose M. Jiménez-Gómez, Jose M. Jiménez-Gómez, Henk W. M. Hilhorst, Wilco Ligterink   +9 more
doaj   +1 more source

PHYSIOLOGICAL APPROACH TO SEED ENHANCEMENT [PDF]

HortScience, 1994
Purchasers of high-value seeds expect strong, uniform, and reliable germination and establishment, even under stress. Enhancement refers to postharvest processes applied to the seed to improve performance. Most enhancement methods involve controlled hydration.
openaire   +1 more source

Effect of elevated CO2 and high temperature on seed-set and grain quality of rice [PDF]

, 2012
Hybrid vigour may help overcome the negative effects of climate change in rice. A popular rice hybrid (IR75217H), a heat-tolerant check (N22), and a mega-variety (IR64) were tested for tolerance of seed-set and grain quality to high-temperature stress at
Craufurd, P. Q., Fitzgerald, M., Jagadish, S. V. K., Lafarge, T., Madan, P., Wheeler, T. R.   +5 more
core   +2 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source