Results 91 to 100 of about 56,614 (300)

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Organic seed priming with curtailed seed rate compensated wheat grains productivity by upgrading anti-oxidant status against terminal drought at flowering and milking

Scientific Reports
Terminal irrigation drought stress is one of the most drastic abiotic stress to diminish the wheat crop development and grains yield in arid regions of the world.
Hamid Nawaz, Haseeb-ur Rehman, Muhammad Zahid Ihsan, Muhammad Shahid Rizwan, Nazim Hussain, Basharat Ali, Rashid Iqbal, Muhammad Usama Hasnain, Mohamed S. Elshikh, Jawaher Alkahtani, Muhammad Arslan   +10 more
doaj   +1 more source

Factors Influencing Seed Dormancy and Germination and Advances in Seed Priming Technology

Plants
Seed dormancy and germination play pivotal roles in the agronomic traits of plants, and the degree of dormancy intuitively affects the yield and quality of crops in agricultural production.
Yanfeng Fu, Li Ma, Juncai Li, Danping Hou, Bo Zeng, Like Zhang, Chunqing Liu, Qingyu Bi, Jinsong Tan, Xinqiao Yu, Junguo Bi, Lijun Luo   +11 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Buzz monitoring in word space [PDF]

, 2008
This paper discusses the task of tracking mentions of some topically interesting textual entity from a continuously and dynamically changing flow of text, such as a news feed, the output from an Internet crawler or a similar text source - a task ...
Karlgren, Jussi, Sahlgren, Magnus
core   +2 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

RNA-Seq using bulked recombinant inbred line populations uncovers the importance of brassinosteroid for seed longevity after priming treatments

Scientific Reports, 2017
Seed priming is a commercially used technique for improving seed performance including germination. However, the treatment sometimes reduces seed longevity as a side effect, limiting the storable period or longevity of the seeds. To overcome this problem,
Naoto Sano, June-Sik Kim, Yoshihiko Onda, Takahito Nomura, Keiichi Mochida, Masanori Okamoto, Mitsunori Seo   +6 more
doaj   +1 more source

Different Modes of Hydrogen Peroxide Action During Seed Germination [PDF]

, 2016
Hydrogen peroxide was initially recognized as a toxic molecule that causes damage at different levels of cell organization and thus losses in cell viability.
Katarzyna eLechowska, Małgorzata eGarnczarska, Szymon eKubala, Szymon eKubala, Łukasz eWojtyla   +4 more
core   +2 more sources

Seed Priming: An Interlinking Technology between Seeds, Seed Germination and Seedling Establishment

, 2022
Biologically seed is a small embryonic plant along with either endosperm or cotyledons, enclosed with in an outer protecting covering called seed coat. During the time of seed development large metabolic conversions take place, including proper partitioning of photo-assimilates and the formation of complex polymeric forms of carbohydrate, protein and ...
Sananda, Mondal,, Bandana, Bose,
openaire   +3 more sources