Results 101 to 110 of about 1,092,233 (309)

Sustainable production of organic wheat [PDF]

open access: yes, 2006
The aim of the project is to use an ecological approach to analyse the interactions of a range of key agronomic variables in organic wheat production (wheat genotype, spatial arrangement of seed, seed density and wheat/white clover bi-cropping) to ...
Clarke, S   +4 more
core  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Multivariate NIR studies of seed-water interaction in Scots Pine Seeds (Pinus sylvestris L.) [PDF]

open access: yes, 2003
This thesis describes seed-water interaction using near infrared (NIR) spectroscopy, multivariate regression models and Scots pine seeds. The presented research covers classification of seed viability, prediction of seed moisture content, selection of ...
Lestander, Torbjörn
core  

Effect of elevated CO2 and high temperature on seed-set and grain quality of rice [PDF]

open access: yes, 2012
Hybrid vigour may help overcome the negative effects of climate change in rice. A popular rice hybrid (IR75217H), a heat-tolerant check (N22), and a mega-variety (IR64) were tested for tolerance of seed-set and grain quality to high-temperature stress at
Craufurd, P. Q.   +5 more
core   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

VARIETAL SALES AND QUALITY DIFFERENTIATION: THE CASE OF CERTIFIED SOYBEAN SEED IN THE SOUTHEASTERN U.S. [PDF]

open access: yes
Variation in annual soybean plantings contributes to uncertainty in supplies of and demand for soybean seed in the southeastern U.S. This study used an expenditure valuation approach in an hedonic analysis framework to estimate returns to soybean seed ...
Fletcher, Stanley M.   +2 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Control of seed borne diseasees in organic seed propagation [PDF]

open access: yes, 2004
Introduction The key control measure of plant diseases in organic agriculture is crop rotation, mixed cropping and moderate fertilization. A wide range of plant diseases can be controlled or minimized in this way.
Borgen, Anders
core  

Strength through diversity: how cancers thrive when clones cooperate

open access: yesMolecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken   +3 more
wiley   +1 more source

Is it possible to check micro ginning fiber quality preservation performance using reference seed-cotton materials? [PDF]

open access: yes, 2016
In sub-Saharian countries, simple micro-gin, without seed-cotton cleaner nor lint-cleaner, is often used as a reference device for characterizing the performance of industrial gin plants for fiber quality preservation.
Gourlot, Jean-Paul   +3 more
core  

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