Results 61 to 70 of about 261,180 (263)

The giant genome of lily provides insights into the hybridization of cultivated lilies

Nature Communications
Lilies are economically important monocots known for their ornamental flowers, bulbs, and large genomes. The absence of their genomic information has impeded evolutionary studies and genome-based breeding efforts.
Yuwei Liang, Qiang Gao, Fan Li, Yunpeng Du, Jian Wu, Wenqiang Pan, Shaokun Wang, Xiuhai Zhang, Mingfang Zhang, Xiaoming Song, Linlin Zhong, Fan Zhang, Yan Li, Zhiwei Wang, Danqing Li, Qing Duan, Shenchong Li, Chunlian Jin, Peihua Zhang, Yang Gu, Zhong-Hua Chen, Klaus F. X. Mayer, Xiaofan Zhou, Jihua Wang, Liangsheng Zhang   +24 more
doaj   +1 more source

Effect of common bean (Phaseolus vulgaris L.) seed viability on drying dynamics

Folia Horticulturae, 2008
‘Tina’ and ‘Libra’ cultivar seeds of the common bean (Phaseolus vulgaris L.) beginning germination capacity of 98%, were subjected to artificial ageing. In the thermal chamber, they were twice treated for 72 hours at 45°C.
Ratajczak Krzysztof, Hołubowicz Roman
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Synergistic effects of enzymatic debranching and high hydrostatic pressure on the structural and digestive properties of –conjugated linoleic acid microcapsules

Food Chemistry: X
This study explored the effects of enzymatic debranching (ED, 0–12 h) and high hydrostatic pressure (HHP, 300–600 MPa) on the multi-scale structure and in vitro digestibility of lotus seed starch (LS)–conjugated linoleic acid (CLA) microcapsules.
Bailong Wang, Ru Jia, Wenjing Chen, Zebin Guo   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Chickpea Variety Assessment in Austria’s Arid Growing Region: Growth, Yield, and Chemical Composition

Die Bodenkultur
Chickpea, a high-quality protein source, is still rarely cultivated in Austrian agriculture, although its high drought tolerance would make it a suitable alternative crop in the eastern arid growing regions, where climate change increasingly causes ...
Bomers Svenja, von Gehren Philipp, Dittinger Julia, Reiter Elisabeth, Wagner Magdalena, Runge Nathalie, Vogl Sylvia   +6 more
doaj   +1 more source

Effect of Pansy (Viola x wittrockiana gams) Seeds Colour and Size on their Germination

Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 2008
Four commercial seed lots from the Polish seed companies of pansy (Viola x wittrockiana Gams) with low germination capacity were sorted into 2 size fractions: small and large: below 4 mm long and above 4 mm and 3 colour fractions: yellow, brown and dark,
Rosinska AGNIESZKA, Roman HOLUBOWICZ
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source