Results 51 to 60 of about 261,180 (263)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
PlantsThe AP2/ERF transcription factor family plays pivotal roles in plant growth, stress responses, and defense mechanisms, yet its diversity in camphor trees remains underexplored.
Jiexi Hou +7 more
doaj +1 more source
A study of the effect of changes in seed comb construction on the quality of cotton seed [PDF]
BIO Web of ConferencesIn Uzbekistan, cotton is a significant agricultural product, serving as raw material for the textile industry and oil factories. Ensuring the quality of cotton fiber and seed is crucial, and this study investigates the factors affecting seed quality ...
Mamasharipov Abdunabi +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
SEED QUALITY OF SELECTED VEGETABLE SPECIES ON THE POLISH MARKET
Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 2006 In the years 2001-2003 the seed quality of 108 samples of white head cabbage, garden carrot, red beet, onion, cucumber, tomato, radish, lettuce, common bean and garden pea were checked.
Tomasz W. BRALEWSKI, Roman HOLUBOWICZ
doaj +1 more source
Vigor test of (strong) normal intact Amburana cearensis (Allemão) A.C. Smith seedlings
Journal of Seed Science, 2020 : The aim of this study was to adapt the vigor test methodology of (strong) normal intact seedlings of Amburana cearensis and evaluate efficiency in physiological classification of seed lots.
Josenilda Aprígio Dantas de Medeiros +5 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
HortScience, 2005 High seed quality is required to obtain optimal plant stands and to achieve maximum yield potential. Onion seeds are commonly coated and treated with an insecticide and fungicide to control early season insects and diseases. The seed treatments may cause phytotoxicity in standard germination tests, and thus reduce the percent germination of a seed lot.
openaire +1 more source