Results 51 to 60 of about 242,399 (261)

Vigor test of (strong) normal intact Amburana cearensis (Allemão) A.C. Smith seedlings

Journal of Seed Science, 2020
: The aim of this study was to adapt the vigor test methodology of (strong) normal intact seedlings of Amburana cearensis and evaluate efficiency in physiological classification of seed lots.
Josenilda Aprígio Dantas de Medeiros, Sarah Patrícia Lima Nunes, Francival Cardoso Félix, Cibele dos Santos Ferrari, Mauro Vasconcelos Pacheco, Salvador Barros Torres   +5 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

SEED QUALITY OF SELECTED VEGETABLE SPECIES ON THE POLISH MARKET

Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 2006
In the years 2001-2003 the seed quality of 108 samples of white head cabbage, garden carrot, red beet, onion, cucumber, tomato, radish, lettuce, common bean and garden pea were checked.
Tomasz W. BRALEWSKI, Roman HOLUBOWICZ
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Effect of common bean (Phaseolus vulgaris L.) seed viability on drying dynamics

Folia Horticulturae, 2008
‘Tina’ and ‘Libra’ cultivar seeds of the common bean (Phaseolus vulgaris L.) beginning germination capacity of 98%, were subjected to artificial ageing. In the thermal chamber, they were twice treated for 72 hours at 45°C.
Ratajczak Krzysztof, Hołubowicz Roman
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

The giant genome of lily provides insights into the hybridization of cultivated lilies

Nature Communications
Lilies are economically important monocots known for their ornamental flowers, bulbs, and large genomes. The absence of their genomic information has impeded evolutionary studies and genome-based breeding efforts.
Yuwei Liang, Qiang Gao, Fan Li, Yunpeng Du, Jian Wu, Wenqiang Pan, Shaokun Wang, Xiuhai Zhang, Mingfang Zhang, Xiaoming Song, Linlin Zhong, Fan Zhang, Yan Li, Zhiwei Wang, Danqing Li, Qing Duan, Shenchong Li, Chunlian Jin, Peihua Zhang, Yang Gu, Zhong-Hua Chen, Klaus F. X. Mayer, Xiaofan Zhou, Jihua Wang, Liangsheng Zhang   +24 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Onion Seed Quality [PDF]

HortScience, 2005
High seed quality is required to obtain optimal plant stands and to achieve maximum yield potential. Onion seeds are commonly coated and treated with an insecticide and fungicide to control early season insects and diseases. The seed treatments may cause phytotoxicity in standard germination tests, and thus reduce the percent germination of a seed lot.
openaire   +1 more source