Results 31 to 40 of about 261,180 (263)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Vigour testing for the rice seed with computer vision-based techniques
Frontiers in Plant Science, 2023 Rice is the staple food for approximately half of the world’s population. Seed vigour has a crucial impact on the yield, which can be evaluated by germination rate, vigor index and etc.
Juxiang Qiao +6 more
doaj +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
, 2023 AbstractWith the expansion of precision and intensive agriculture, seed quality, which alone could contribute up to 15–20 per cent in terms of crop productivity, has assumed greater importance. Every care is taken not only to produce high-quality seeds and maintain the same through various stages of production, from growing conditions of the seed crop ...
Weissmann, Elmar A. +4 more
openaire +2 more sources
Evaluation of Priming Techniques for Enhancement of Maize Inbred Line Seed Germination Parameters
International Journal of AgronomyDue to inadequate germination, emergence, and seedling stand establishment of inbred lines, hybrid seed multiplication results in poor performance and nonuniform seedlings in the field.
Getahun Bekele +2 more
doaj +1 more source
Open Agriculture, 2023 Farmers are accessing seeds from different sources with different quality standards. Studies on the assessment of seed systems (sources) in relation to seed quality are scarce.
Yitayew Yekoye Abebaw +2 more
doaj +1 more source
Frontiers in Plant Science, 2023 Water spinach (Ipomoea aquatica Forsk) is an essential green leafy vegetable in Asia. In this study, we induced autotetraploid water spinach by colchicine. Furthermore, DNA methylation and transcriptome of tetraploid and diploid were compared using Whole
Yuanyuan Hao +20 more
doaj +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source