Results 71 to 80 of about 120,511 (338)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Vigor de sementes e desempenho produtivo de híbridos de milho [PDF]

, 2014
The relationship between seed vigor and performance are quite contradictory. For species that produce grains and vegetables, the effects of seed vigor can be expressed in the emergence, early growth, and development, with impacts on final yield. However,
Silva, Danilo Henrique Rodrigues da
core   +1 more source

Report on identifying a protocol to elicit flowering in Brachiaria humidicola with photoperiod management [PDF]

, 2020
Two Genotypes of Brachiaria humidicola (A and B) were planted on the grounds of CIAT headquarters in Palmira during 2018 – 2019, 10 lamps were placed in the lot to evaluate 6 different photoperiods (1 - 6) with Light in 2 different wavelength range (W.R.)
Castiblanco, Valheria, Florián, David, Hernández, Luis Miguel   +2 more
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Effects of Purple Seed Stain on Seed Quality and Composition in Soybean

Plants, 2020
Purple seed stain disease, caused by (Cercospora kukuchii), is a major concern in soybean (Glycine max (L.)) in Mississippi, USA, due to its effects on seed quality, reducing soybean seed grade and potential market price at elevators.
Richard E. Turner, M. Wayne Ebelhar, Teresa Wilkerson, Nacer Bellaloui, Bobby R. Golden, J. Trenton Irby, Steve Martin   +6 more
doaj   +1 more source

Effects of Nanosilica Powder from Rice Hull Ash on Seed Germination of Tomato (Lycopersicon esculentum) [PDF]

, 2015
open5noNanosilica powders were synthesized from rice hull ash (RHA) and their effects on seed germination of tomato plants were investigated. Synthesized nanosilica powder was subjected to various characterization studies for identification of the size ...
De Silva, Diana Marie, Engelbert, Peralta, Fajardo, Alvin., Maria Morissa Lu,, Milagros, Peralta   +4 more
core  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Genome-Wide Association Analysis of Seed Vigor-Related Traits in Wheat

Agronomy
Seed vigor is a crucial indicator comprehensively assessing the quality of seeds, reflecting the growth advantage and production potential of seeds, and has a significant effect on seeds’ stress resistance.
Qinxuan Wu, Bingxin Shi, Yao Lai, Yuanyuan Zhang, Yu Wu, Zhi Li, Yang Li, Xiaofei Zhu, Zhien Pu, Zihui Liu   +9 more
doaj   +1 more source

Methylation status of ACCase promoter affects seed vigor-viability trait in Oryza sativa L. [PDF]

Tropical Plant Research, 2018
Rice (Oryza sativa L.) varieties exhibiting phenotypic features of high/low seed vigor-viability were used to explore genetic controls associated with a varietal difference in seed vigor and viability traits. Since germination rate i.e.
Subhabrata Ghosh, Swati Sen-Mandi
doaj   +1 more source