Results 71 to 80 of about 23,811 (279)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Vigor-S: system for automated evaluation of soybean seed vigor

, 2019
O uso de sistemas computadorizados de análise de imagens de sementes ou de plântulas pode ser uma alternativa para diminuir a subjetividade e aumentar a rapidez da avaliação do potencial fisiológico de sementes.
Mayara Rodrigues, Rodrigues, Mayara
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Genome-Wide Association Analysis of Seed Vigor-Related Traits in Wheat

Agronomy
Seed vigor is a crucial indicator comprehensively assessing the quality of seeds, reflecting the growth advantage and production potential of seeds, and has a significant effect on seeds’ stress resistance.
Qinxuan Wu, Bingxin Shi, Yao Lai, Yuanyuan Zhang, Yu Wu, Zhi Li, Yang Li, Xiaofei Zhu, Zhien Pu, Zihui Liu   +9 more
doaj   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Seedling image analysis and traditional tests to evaluate onion seed vigor

Journal of Seed Science
: The aim of this study was to verify the possibility of using computerized seedling image analysis to detect differences in vigor among onion seed lots and to compare this analysis with traditional vigor tests.
Nayara Roberto Gonçalves, Silvio Moure Cicero, Haynna Fernandes Abud   +2 more
doaj   +1 more source

Analysis of seed vigor in relation to storability of pepper (capsicum annuum l.) seedand its genetic parameter estimation.

, 2012
The abilityof seedtomaintainseed qualityduringstorageis calledseed vigor.Selectionmethodfor testingseed vigor of pepper seeds is necessarytodetermineseed vigor in relation to seed storability duringthe process ofmarketingand distribution.
Prihastuti Ekowahyuni, Luluk
core  

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Relationship between seed harvesting method and seed physiological quality for a number of Pioneer maize hybrids

, 2012
The seed germination and seed vigor of eight Pioneer Hi-Bred maize hybrids were evaluated immediately after harvesting and a year later. The aim was to determine whether the seed showed loss of germination and vigor when shelled mechanically.
Berzy, Tamás, Anda, Angéla, Varga, Péter, Ertsey, Katalin   +3 more
core  

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source