Results 51 to 60 of about 185,882 (313)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Effective morphological and phenological traits on seed and biological yield in lentil genotypes in Shahrekord region [PDF]

پژوهش‌های حبوبات ایران, 2012
In order to study the phenological and morphological characteristics, comparison of yield and yield components, correlation between traits and determination of the parameters affecting seed yield, a field experiment was carried out at the Research Farm ...
Ali Tadayyon, Lida Hashemi, Mahmod Khodambashi   +2 more
doaj   +1 more source

The effects of cereal rye cover crop seeding rate, termination timing, and herbicide inputs on weed control and soybean yield [PDF]

, 2023
Alyssa I. Essman, Mark M. Loux, Alexander J. Lindsey, Anthony F. Dobbels   +3 more
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Production of alfalfa seed yield [PDF]

, 2003
U radu je dat pregled osnovnih tehnoloških operacija važnih za uspešnu proizvodnju lucerkinog semena. Dat je pregled izbora najoptimalnijeg otkosa u pojedinim godinama proizvodnje, značaj meteoroloških uslova u toku proizvodnje, optimalan način i gustina setve, optimalne preporuke za đubrenje semenskog useva. U radu je iznesena problematika oprašivanja
Vučković, Savo, Simić, Aleksandar, Krstanović, Saša, Stojanović, Ivana, Stanisavljević, R., Vojin, Svetko, Vučković, Marina   +6 more
openaire  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Optimizing zinc seed coating treatments for improving growth, productivity and grain biofortification of mungbean

Soil & Environment, 2019
Zinc (Zn) is a crucial micronutrient required by plants and human beings. In this study, it was hypothesized that Zn seed coating may improve the stand establishment, growth, grain Zn biofortification and seed yield of mungbean (Vigna radiata (L ...
Muhammad Umar Haider, Mubshar Hussain, Muhammad Farooq   +2 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

FIELD PEA (PISUM SATIVUM L.) BIOMASS PRODUCTION DEPENDED ON SEED AGE AND AGROECOLOGICAL GROWTH CONDITIONS [PDF]

Poljoprivreda, 2006
Influence of weather conditions and seed age on fresh and dry biomass production, field germination, seed yield and 1000 seed weight of field pea were investigated in field trials during two years at two locations of East Croatia (Osijek and Vinkovci ...
Irena Rapčan, Gordana Bukvić, Sonja Grljušić, Tihana Teklić, M. Jurišić   +4 more
doaj