Results 101 to 110 of about 116,110 (259)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Impact of Cell Seeding Density and Cell Confluence on Human Tissue Engineered Skeletal Muscle. [PDF]

Tissue Eng Part A, 2022
Wroblewski OM, Nguyen MH, Cederna PS, Larkin LM.   +3 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Application of metabolic modeling for targeted optimization of high seeding density processes. [PDF]

Biotechnol Bioeng, 2021
Brunner M, Kolb K, Keitel A, Stiefel F, Wucherpfennig T, Bechmann J, Unsoeld A, Schaub J.   +7 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

β-catenin links cell seeding density to global gene expression during mouse embryonic stem cell differentiation. [PDF]

iScience, 2022
LeBlanc L, Kim M, Kambhampati A, Son AJ, Ramirez N, Kim J.   +5 more
europepmc   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Genetic and management adaptation of field bean (Vicia faba L.) in Finland

Agricultural and Food Science, 1981
The investigation of field bean adaptation in Finnish climatic conditions was carried out at the University of Helsinki in 1976—77. The main objectives were to study the effects of seeding time and population density on the quantity and quality of the ...
Seppo Pulli, Mauritz Vestberg
doaj  

Organic Lentil Production in Switzerland: Evaluation of Genotypes for Agronomical, Qualitative, and Sensory Traits

Agronomy
Lentils constitute a strategically important crop within sustainable agricultural systems, particularly in the context of rising global demand for plant-based protein sources.
Anna Blatter, Katrin Rehak, Despoina Sidiropoulou, Jonas Inderbitzin, Jürg Hiltbrunner   +4 more
doaj   +1 more source

Optimizing interleukin-2 concentration, seeding density and bead-to-cell ratio of T-cell expansion for adoptive immunotherapy. [PDF]

BMC Immunol, 2021
Ghaffari S, Torabi-Rahvar M, Aghayan S, Jabbarpour Z, Moradzadeh K, Omidkhoda A, Ahmadbeigi N.   +6 more
europepmc   +1 more source