Results 41 to 50 of about 327,495 (306)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Dry Bean Seeding Rate Trial [PDF]

, 2016
Dry beans (Phaseolus vulgaris), a high-protein pulse crop, have been grown in the Northeast since the 1800’s. As the local food movement expands, consumers have requested stores stock more and more locally produced foods, and heirloom dry beans are no ...
Cummings, Erica, Darby, Heather
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Study on the excess seeds removing performance of a potato precision seed metering device

Scientific Reports
In the potato mechanical planting industry, the high multi-seeding rate and miss-seeding rate are problems that exist in many potato precision seed metering devices. The main potato seeds in China are cut potatoes with different shapes and sizes. However,
Jiarui Wang, Min Liao, Chao Su, Rui Chen, Hailong Xia, Junju Li, Chenyang Qiao   +6 more
doaj   +1 more source

Seeding Rate Effects on Forage Mass and Vegetation Dynamics of Cool-Season Grass Sod Interseeded with Sorghum-Sudangrass

Agronomy, 2021
Interseeding annual warm-season grasses into perennial cool-season grasses has the potential to increase summer forage mass and nutritive value. Knowledge of how seeding rate affects annual warm-season grass establishment, forage mass, and vegetation ...
John A. Guretzky, Daren D. Redfearn
doaj   +1 more source

Industrial Hemp Seeding Rate Trial [PDF]

, 2016
Hemp is a non-psychoactive variety of cannabis sativa L. The crop is one of historical importance in the U.S. and reemerging worldwide importance as manufacturers seek hemp as a renewable and sustainable resource for a wide variety of consumer and ...
Cubins, Julija, Darby, Heather, Gupta, Abha, Ruhl, Lindsey, Ziegler, Sara, University of Vermont   +4 more
core   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

The effect of sowing dates and seeding rates on productivity of wintering peas in the southern part of the Rostov region

Зерновое хозяйство России, 2023
The current paper has presented the study results on the effect of sowing dates and seeding rates on productivity of wintering peas. Field trials were carried out during 2019–2021.
S. A. Vasilchenko, G. V. Metlina, A. R. Ashiev   +2 more
doaj   +1 more source

Spring Barley Seeding Rate and Interseeding Trial [PDF]

, 2015
With the revival of the small grains industry in the Northeast and the strength of the localvore movement, craft breweries and distilleries have expressed an interest in sourcing local barley for malting.
Calderwood, Lily, Cubins, Julija, Cummings, Erica, Darby, Heather, Gupta, Abha, Post, Julian, Ziegler, Sara   +6 more
core   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source