Results 61 to 70 of about 136,113 (261)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Design and Testing of a Branched Air-Chamber Type Pneumatic Seed Metering Device for Rice
AgricultureTo meet the diverse seeding requirements of super hybrid rice, common hybrid rice, and conventional rice—which vary from 1 to 3 seeds, 2 to 4 seeds, and 5 to 8 seeds per hole, respectively—this study developed a branched air-chamber type pneumatic seed ...
Xiantao Zha +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Design of air-aspiration drum type tray precision seeding streamline
浙江大学学报. 农业与生命科学版, 2018 Aimed at lack of automated assembly line in the domestic vegetable seedling production field, combined with the seeding process of domestic vegetable seeds, the air-aspiration drum type tray precision seeding streamline was designed.
MA Guang
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
AgricultureSeeding depth is a critical factor influencing the uniformity and vigor of wheat seedlings. To address inconsistent seeding depth in wide-row uniform seeding agricultural practices, we performed parameter analysis and optimization experiments on the ...
Longfei Yang +6 more
doaj +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
RESPONSE OF OAT CULTIVARS TO DIFFERENT SEEDING RATES
The Iraqi Journal of Agricultural scienceThis study was aimed to investigate vegetative growth indicators of four oat cultivars (Genzania, Shefa, Carrolup, and Hamel) at seeding rates of 80, 100, and 120 kg ha⁻¹ in a factorial experiment within a randomized block design during the winter ...
Basheer A. Abraheem +1 more
doaj +1 more source