Results 81 to 90 of about 136,113 (261)

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

open access: yesMolecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy   +10 more
wiley   +1 more source

Impact of peanut seeding rate on water-use efficiency and yield

open access: yesFrontiers in Agronomy
Seeds account for one of the highest costs in peanut production. Moreover, the climate in most of the Southeastern US is predicted to become drier and warmer throughout the growing season. Thus, this paper examines how seeding rates alter ecosystem water-
Gengsheng Zhang   +4 more
doaj   +1 more source

Construction of dominant rice population under dry cultivation by seeding rate and nitrogen rate interaction. [PDF]

open access: yesSci Rep, 2021
Jiang H   +13 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Field performance optimization and experimental study of an integrated mobile platform for precision rice seeding operations

open access: yesFrontiers in Sustainable Food Systems
ObjectiveDirect-seeded rice in Northeast China’s cold regions demands extremely high seeding quality, but black soil adhesion and low-temperature environments cause existing seeding technologies to fail.
Yan Ye
doaj   +1 more source

Effect of Ultrasonic Ice Seeding on Cryopreservation of L-02 Hepatocyte

open access: yesZhileng xuebao, 2021
During the slow freezing process, the cell solution is super-cooled, which may cause uncontrollable intracellular ice formation. Ultrasonic ice seeding can reduce super-cooling and improve the cell survival rate.
Li Weijie   +3 more
doaj  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

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