Results 161 to 170 of about 2,141,304 (303)

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Evading regulation: young people's exposure to harmful commodity marketing in the social media feeds of their favourite influencers. [PDF]

Health Promot Int
Lyons AC, Goodwin I, Young J, Burton-Wood C.   +3 more
europepmc   +1 more source

Seeing is believing [PDF]

, 2000
Brennan, Andrei S. P.
core   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Exploring online and in-person mental healthcare access and app use in a cohort of people living with disability: results from the 2019 and 2020 California Health Interview Survey. [PDF]

Internet Interv
Bevens W, Kim J, Cha B, Stadnick NA, Eikey E, Schneider M, Schueller SM, Mukamel DB, Sorkin DH.   +8 more
europepmc   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Disrupting stigma associated with dementia and dance through documentary film. [PDF]

BMC Public Health
Kontos P, Grigorovich A, Colobong R, Sodums D, Vijinski JP, Aleong R, Bar RJ.   +6 more
europepmc   +1 more source

Seeing red by accident? [PDF]

, 2007
Chittka, L, Chittka, L
core  

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Exploring Patient-Reported Gingival Health in Adults Using Standardised International FDI Oral Health Observatory Data. [PDF]

Int Dent J
Broomhead T, Kettle J, Mason S, Baker S.
europepmc   +1 more source