Results 111 to 120 of about 109,939 (312)

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Proportion of early-stage breast cancer cases receiving intensity modulated radiation therapy following lumpectomy by Surveillance, Epidemiology, and End Results (SEER) registry in the SEER-medicare database.

open access: yes, 2019
Proportion of early-stage breast cancer cases receiving intensity modulated radiation therapy following lumpectomy by Surveillance, Epidemiology, and End Results (SEER) registry in the SEER-medicare database.
Qin Sun (1832275)   +6 more
core   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

open access: yesFEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Descriptive Epidemiology of Adult Liposarcoma: A Population-based Study Using SEER and the Combined SEER/NPCR Databases, 2001-2016

open access: yes, 2020
DESCRIPTIVE EPIDEMIOLOGY OF ADULT LIPOSARCOMA: A POPULATION-BASED STUDY USING SEER AND THE COMBINED SEER/NPCR DATABASES, 2001-2016 SUZANNE BOCK November 12, 2019 INTRODUCTION: Rare cancers, affecting 1 in 5 cancer patients, disproportionally contribute
Bock, Suzanne
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Dragon seer

open access: yes, 2009
A slave since childhood, Madoc has always watched the dragons from afar. But in a twist of fate she is chosen to be the next dragon seer, one who will care for the mysterious creatures and learn their magic ...
McNaughton, Janet Elizabeth 1953-
core  

Pancreatic cancer data(from SEER)

open access: yes
The pancreatic cancer patients data from SEER between 2001 and ...
Xu, Benhua
core   +1 more source

Study on Regional SEER of Frequency Conversion Room Air Conditioner

open access: yes, 2005
The calculated formula of SEER in JRA4046-1999 and GB7725 was analyzed and modified for convenient use. The map of Chinese temperature-strip was given and the weather data for eight cities near 30 years were selected.
刘圣春, 马一太, 成建宏
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

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