Results 81 to 90 of about 233,573 (293)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Application of Machine Learning Techniques to Predict Bone Metastasis in Patients with Prostate Cancer

Cancer Management and Research, 2021
Wen-Cai Liu,1,2 Ming-Xuan Li,2 Wen-Xing Qian,3 Zhi-Wen Luo,1,4 Wei-Jie Liao,1,4 Zhi-Li Liu,1,4 Jia-Ming Liu1,4 1Department of Orthopaedic Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, 330006, People’s Republic of China; 2The ...
Liu WC, Li MX, Qian WX, Luo ZW, Liao WJ, Liu ZL, Liu JM   +6 more
doaj  

Informatics research using publicly available pathology data

Journal of Pathology Informatics, 2011
The day has not arrived when pathology departments freely distribute their collected anatomic and clinical data for research purposes. Nonetheless, several valuable public domain data sets are currently available, from the U.S. Government.
Jules J Berman
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Construction and Validation of Two Novel Nomograms for Predicting the Overall Survival and Cancer-Specific Survival of NSCLC Patients with Bone Metastasis

International Journal of General Medicine, 2021
Qiu Dong,1 Jialin Deng,2 Tsz Ngai Mok,1 Junyuan Chen,1 Zhengang Zha1 1Center for Bone, Joint and Sports Medicine, The First Hospital of Jinan University, Jinan University, Guangzhou, Guangdong, People’s Republic of China; 2School of Medicine, Jinan ...
Dong Q, Deng J, Mok TN, Chen J, Zha Z
doaj  

Mean and fluctuating velocity contours and acoustic characteristics of subsonic and supersonic jets [PDF]

Shadowgraph photographs of subsonic and supersonic ...
Bigelow, E. C., Nagamatsu, H. T., Seer, R. E., Jr.   +2 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Primary tumor size as a prognostic factor in duodenal neuroendocrine neoplasms ≤20 mm: a population-based SEER analysis

Endocrine Oncology
Objective: The prognostic value of primary tumor size in duodenal neuroendocrine neoplasms (dNENs) ≤20 mm remains uncertain. Although size is used to guide management, its independent effect on survival is unclear.
Giuseppe Lamberti, Francesco Panzuto, Maria Rinzivillo, Flaminia Benedetta Zoboli, Irene Zannini, Elisa Andrini, Elisabetta Dell’Unto, Riccardo Di Pangrazio, Davide Campana   +8 more
doaj   +1 more source

A Prognostic Scoring System for Predicting Overall Survival of Patients with the TNM 8th Edition Stage I and II Hepatocellular Carcinoma After Surgery: A Population-Based Study

Cancer Management and Research, 2021
Yannan Bai,1,* Yuan’e Lian,2,* Jiayi Wu,1 Shi Chen,1 Jianlin Lai,1 Yu Zheng,1 Yifeng Tian,1 Maolin Yan,1 Yaodong Wang1 1Hepatobiliary Surgery Department, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital ...
Bai Y, Lian Y, Wu J, Chen S, Lai J, Zheng Y, Tian Y, Yan M, Wang Y   +8 more
doaj  

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source